Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | PIR | O00625 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 6/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45469 | 0.88 | KDM4E (0.67) | KDM4EMAPTPLAUSMYD3HDAC8 | |
| SCHEMBL16061494 | 0.88 | KDM4E (0.59) | KDM4EMAPTPLAUPIRGSK3B | |
| SCHEMBL45245 | 0.87 | KDM4E (0.65) | KDM4EMAPTPLAUPIRGSK3B | |
| SCHEMBL45353 | 0.78 | KDM4E (0.68) | KDM4EMAPTPLAUPIRGSK3B | |
| SCHEMBL45202 | 0.77 | KDM4E (1.00) | KDM4EMAPTPLAUPIRGSK3B | |
| SCHEMBL29673258 | 0.77 | KDM4E (1.00) | KDM4EMAPTPLAUPIRGSK3B | |
| SCHEMBL45745 | 0.76 | MAPT (0.64) | KDM4EMAPTPLAUPIRGSK3B | |
| SCHEMBL29521140 | 0.74 | SMYD3 (0.45) | SMYD3 | |
| SCHEMBL16984422 | 0.73 | CRBN (0.57) | KDM4EMAPTSMYD3CRBN | |
| SCHEMBL3096482 | 0.73 | MAPT (0.73) | KDM4EMAPTPLAUPIRGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588458-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-08 | — | — | EP | claimed |
| WO-2012001020-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-05 | — | — | WO | claimed |