Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | SMYD3 | Q9H7B4 | 13/20 | 0.58 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | PRKACG | P22612 | 1/20 | 0.47 |
| ▸ | PRKACB | P22694 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45245 | 0.96 | KDM4E (0.65) | KDM4EMAPTSMYD3CRBNPLAU | |
| SCHEMBL16061494 | 0.91 | KDM4E (0.59) | KDM4EMAPTSMYD3CRBNPLAU | |
| SCHEMBL45293 | 0.88 | KDM4E (0.62) | KDM4EMAPTSMYD3CRBNPLAU | |
| SCHEMBL16984422 | 0.82 | CRBN (0.57) | KDM4EMAPTSMYD3CRBNPRKACA | |
| SCHEMBL15616400 | 0.82 | MAPK14 (0.53) | KDM4EMAPTSMYD3HDAC8 | |
| SCHEMBL45353 | 0.81 | KDM4E (0.68) | KDM4EMAPTCRBNPLAUHDAC8 | |
| SCHEMBL29673258 | 0.81 | KDM4E (1.00) | KDM4EMAPTPLAU | |
| SCHEMBL45202 | 0.81 | KDM4E (1.00) | KDM4EMAPTPLAU | |
| SCHEMBL45745 | 0.79 | MAPT (0.64) | KDM4EMAPTPLAU | |
| SCHEMBL3096482 | 0.76 | MAPT (0.73) | KDM4EMAPTPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588458-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-08 | — | — | EP | claimed |
| WO-2012001020-A1 | NOVEL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-05 | — | — | WO | claimed |