Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 17/20 | 0.68 |
| ▸ | HPGD | P15428 | 10/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 17/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.68 |
| ▸ | CASP1 | P29466 | 4/20 | 0.68 |
| ▸ | CASP7 | P55210 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31351814 | 0.88 | KDM4E (0.71) | ALDH1A1HPGDSMN1; SMN2TAAR1KDM4E | |
| SCHEMBL31351800 | 0.84 | KDM4E (0.76) | ALDH1A1HPGDKDM4EHSD17B10CASP1 | |
| SCHEMBL1718368 | 0.82 | ALDH1A1 (0.69) | ALDH1A1HPGDSMN1; SMN2TAAR1KDM4E | |
| SCHEMBL14039102 | 0.81 | KDM4E (0.61) | ALDH1A1HPGDSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL31351798 | 0.81 | KDM4E (0.68) | ALDH1A1HPGDKDM4EHSD17B10CASP1 | |
| SCHEMBL4204381 | 0.80 | KDM4E (0.69) | ALDH1A1HPGDSMN1; SMN2TAAR1KDM4E | |
| SCHEMBL31351828 | 0.80 | KDM4E (0.73) | ALDH1A1HPGDKDM4EHSD17B10CASP1 | |
| SCHEMBL4211090 | 0.79 | KDM4E (1.00) | ALDH1A1HPGDSMN1; SMN2TAAR1KDM4E | |
| SCHEMBL31351806 | 0.77 | KDM4E (0.77) | ALDH1A1HPGDSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL31351804 | 0.77 | KDM4E (0.77) | ALDH1A1HPGDSMN1; SMN2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009073460-A2 | INHIBITION OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 FOR OCULAR NEUROPROTECTION | BAUSCH & LOMB INCORPORATED (US) | 2009-06-11 | — | — | WO | disclosed |