Wortmannin

Wortmannin

SCHEMBL4531

COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIK3C3 Q8NEB9 10/20 1.00
PIK3CA P42336 8/20 1.00
PIK3R1 P27986 5/20 1.00
ALDH1A1 P00352 3/20 1.00
MAPT P10636 3/20 1.00
RECQL P46063 3/20 1.00
MTOR P42345 3/20 1.00
THRB P10828 2/20 1.00
MEN1 O00255 2/20 1.00
HPGD P15428 2/20 1.00
KMT2A Q03164 2/20 1.00
HSD17B10 Q99714 2/20 1.00
PRKDC P78527 2/20 1.00
PIK3CD O00329 2/20 1.00
PIK3CG P48736 2/20 1.00
ABCC4 O15439 1/20 1.00
ABCB11 O95342 1/20 1.00
HSP90AA1 P07900 1/20 1.00
PIK3CB P42338 1/20 1.00
PI4KA P42356 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Wortmannin SCHEMBL1147299 1.00 PIK3C3 (1.00) PIK3C3PIK3CAPIK3R1ALDH1A1MAPT
Wortmannin SCHEMBL19737003 1.00 PIK3C3 (1.00) PIK3C3PIK3CAPIK3R1ALDH1A1MAPT
Wortmannin SCHEMBL12650003 1.00 PIK3C3 (1.00) PIK3C3PIK3CAPIK3R1ALDH1A1MAPT
Wortmannin SCHEMBL4896797 1.00 PIK3C3 (1.00) PIK3C3PIK3CAPIK3R1ALDH1A1MAPT
Wortmannin SCHEMBL18022829 1.00 PIK3C3 (1.00) PIK3C3PIK3CAPIK3R1ALDH1A1MAPT
Wortmannin SCHEMBL12162186 1.00 PIK3C3 (1.00) PIK3C3PIK3CAPIK3R1ALDH1A1MAPT
Wortmannin SCHEMBL14174545 1.00 PIK3C3 (1.00) PIK3C3PIK3CAPIK3R1ALDH1A1MAPT
Wortmannin SCHEMBL14233191 1.00 PIK3C3 (1.00) PIK3C3PIK3CAPIK3R1ALDH1A1MAPT
Wortmannin SCHEMBL13166020 1.00 PIK3C3 (1.00) PIK3C3PIK3CAPIK3R1ALDH1A1MAPT
Wortmannin SCHEMBL4530 1.00 PIK3C3 (1.00) PIK3C3PIK3CAPIK3R1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 21277 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
US-20260130949-A1 PANCREATIC CELLS FOR TREATING DIABETES AND METHODS OF GENERATING THE SAME Seraxis, Inc. (US) 2026-05-14 US claimed
EP-4739678-A2 AGE-MODULATING COMPOUNDS AND METHODS FOR MAKING AGE-MODULATED CELLS Memorial Sloan Kettering Cancer Center (US) 2026-05-13 EP claimed
CN-122028940-A PI4K inhibitor and application thereof 清华大学 2026-05-12 CN claimed
CN-122028920-A Method for treating hematological cancer 丹娜-法伯癌症研究院 2026-05-12 CN claimed
US-20260125647-A1 AGE-MODULATING COMPOUNDS AND METHODS FOR MAKING AGE-MODULATED CELLS MEMORIAL SLOAN-KETTERING CANCER CENTER (US) 2026-05-07 US claimed
US-20260102500-A1 PKC INHIBITORS FOR THE TREATMENT OF SEPTIC CHOLESTASIS WITH POLYMETHINE DYE TARGETING SMARTDYELIVERY GMBH (DE) 2026-04-16 US claimed
US-20260097028-A1 Methods of Treating Myeloproliferative Neoplasms KARTOS THERAPEUTICS INC (US) 2026-04-09 US claimed
US-20260090969-A1 COMPOSITIONS THAT PROTECT CELLS FROM OXIDATIVE AND MITOCHONDRIAL STRESS Nuchido Limited (GB) 2026-04-02 US claimed
US-20260077047-A1 CANCER THERAPY Turbine Simulated Cell Technologies Ltd (GB) 2026-03-19 US claimed
WO-1998055602-A9 SCREENING FOR PHOSPHATIDYLINOSITOL RELATED-KINASE INHIBITORS MAYO FOUNDATION (US) 1999-04-08 WO claimed
WO-1998055602-A1 SCREENING FOR PHOSPHATIDYLINOSITOL RELATED-KINASE INHIBITORS MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 1998-12-10 WO claimed
WO-1998051702-A1 METHODS AND COMPOSITIONS FOR DESTRUCTION OF SELECTED PROTEINS SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1998-11-19 WO claimed
EP-0862622-A1 RAC-PROTEINE KINASE AS THERAPEUTIC AGENT OR IN DIAGNOSTICS Novartis AG (CH) 1998-09-09 EP claimed
WO-1998032864-A2 NOVEL LIPID KINASE LUDWIG INSTITUTE FOR CANCER RESEARCH (GB) 1998-07-30 WO claimed
WO-1997018303-A1 RAC-PROTEINE KINASE AS THERAPEUTIC AGENT OR IN DIAGNOSTICS NOVARTIS AG (CH) 1997-05-22 WO claimed
WO-1997015658-A1 WORTMANNIN PHOSPHOINOSITIDE 3-KINASE INTERACTION SITE LUDWIG INSTITUTE FOR CANCER RESEARCH (CH) 1997-05-01 WO claimed
EP-0758232-A1 METHODS FOR MODULATING T CELL RESPONSES BY MANIPULATING INTRACELLULAR SIGNAL TRANSDUCTION THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE NAVY (US) 1997-02-19 EP claimed
WO-1995029673-A1 METHODS FOR MODULATING T CELL RESPONSES BY MANIPULATING INTRACELLULAR SIGNAL TRANSDUCTION THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1995-11-09 WO claimed
EP-0610519-A1 ANTI-HIV DRUG KYOWA HAKKO KOGYO CO., LTD. (JP) 1994-08-17 EP claimed