Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 10/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 8/20 | 1.00 |
| ▸ | PIK3R1 | P27986 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | RECQL | P46063 | 3/20 | 1.00 |
| ▸ | MTOR | P42345 | 3/20 | 1.00 |
| ▸ | THRB | P10828 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | PRKDC | P78527 | 2/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 2/20 | 1.00 |
| ▸ | PIK3CG | P48736 | 2/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 1.00 |
| ▸ | PIK3CB | P42338 | 1/20 | 1.00 |
| ▸ | PI4KA | P42356 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Wortmannin SCHEMBL1147299 | 1.00 | PIK3C3 (1.00) | PIK3C3PIK3CAPIK3R1ALDH1A1MAPT | |
| Wortmannin SCHEMBL19737003 | 1.00 | PIK3C3 (1.00) | PIK3C3PIK3CAPIK3R1ALDH1A1MAPT | |
| Wortmannin SCHEMBL12650003 | 1.00 | PIK3C3 (1.00) | PIK3C3PIK3CAPIK3R1ALDH1A1MAPT | |
| Wortmannin SCHEMBL4896797 | 1.00 | PIK3C3 (1.00) | PIK3C3PIK3CAPIK3R1ALDH1A1MAPT | |
| Wortmannin SCHEMBL18022829 | 1.00 | PIK3C3 (1.00) | PIK3C3PIK3CAPIK3R1ALDH1A1MAPT | |
| Wortmannin SCHEMBL12162186 | 1.00 | PIK3C3 (1.00) | PIK3C3PIK3CAPIK3R1ALDH1A1MAPT | |
| Wortmannin SCHEMBL4531 | 1.00 | PIK3C3 (1.00) | PIK3C3PIK3CAPIK3R1ALDH1A1MAPT | |
| Wortmannin SCHEMBL14174545 | 1.00 | PIK3C3 (1.00) | PIK3C3PIK3CAPIK3R1ALDH1A1MAPT | |
| Wortmannin SCHEMBL14233191 | 1.00 | PIK3C3 (1.00) | PIK3C3PIK3CAPIK3R1ALDH1A1MAPT | |
| Wortmannin SCHEMBL4530 | 1.00 | PIK3C3 (1.00) | PIK3C3PIK3CAPIK3R1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249205-A1 | Metabolites of Wortmannin Analogs and Methods of Using Same | ARIZONA BOARD OF REGENTS (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249205-A1 | Metabolites of Wortmannin Analogs and Methods of Using Same | PPIP5K2, MTMR1, PIP4K2A | PIK3C3 39/4885PIK3CA 6/4885PIK3R1 36/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.