Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.81 |
| ▸ | ROCK1 | Q13464 | 16/20 | 0.81 |
| ▸ | GSK3B | P49841 | 4/20 | 0.70 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.70 |
| ▸ | GSK3A | P49840 | 3/20 | 0.70 |
| ▸ | PRKACA | P17612 | 2/20 | 0.70 |
| ▸ | PRKX | P51817 | 2/20 | 0.70 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.70 |
| ▸ | CDK8 | P49336 | 1/20 | 0.70 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.55 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.55 |
| ▸ | AKT1 | P31749 | 3/20 | 0.55 |
| ▸ | NEK4 | P51957 | 3/20 | 0.55 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.55 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.55 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.55 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | PRKCG | P05129 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4526981 | 1.00 | ROCK2 (0.81) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL4533393 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL4531729 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL16227497 | 0.90 | ROCK2 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL24859313 | 0.83 | ROCK2 (0.74) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL3240825 | 0.82 | ROCK2 (1.00) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL3111251 | 0.82 | ROCK1 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL3109522 | 0.82 | ROCK1 (1.00) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL24859336 | 0.81 | ROCK2 (0.71) | ROCK2ROCK1GSK3BCLK4GSK3A | |
| SCHEMBL4533295 | 0.79 | ROCK2 (0.68) | ROCK2ROCK1GSK3BCLK4GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
| WO-2007026920-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | ROCK2 2/4885ROCK1 1/4885GSK3B 89/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.