Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.72 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.72 |
| ▸ | EPHA2 | P29317 | 4/20 | 0.72 |
| ▸ | EGFR | P00533 | 15/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.69 |
| ▸ | FLT4 | P35916 | 2/20 | 0.69 |
| ▸ | FBP1 | P09467 | 2/20 | 0.69 |
| ▸ | AURKA | O14965 | 1/20 | 0.69 |
| ▸ | INSR | P06213 | 1/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.69 |
| ▸ | CLK1 | P49759 | 1/20 | 0.69 |
| ▸ | TEK | Q02763 | 1/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.69 |
| ▸ | CIT | O14578 | 1/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.63 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9259 | 0.94 | KDR (0.77) | KDREPHB4EPHA2EGFRERBB2 | |
| SCHEMBL4359307 | 0.86 | EPHA2 (0.85) | KDREPHB4EPHA2EGFRERBB2 | |
| SCHEMBL4539126 | 0.86 | EGFR (0.74) | KDREPHB4EPHA2EGFRERBB2 | |
| SCHEMBL7814454 | 0.85 | EPHB4 (0.68) | KDREPHB4EPHA2EGFRERBB2 | |
| SCHEMBL7812296 | 0.85 | EPHB4 (0.68) | KDREPHB4EPHA2EGFRERBB2 | |
| SCHEMBL906997 | 0.84 | EPHA2 (1.00) | KDREPHB4EPHA2EGFRERBB2 | |
| SCHEMBL2099106 | 0.83 | EGFR (1.00) | KDREPHB4EGFRERBB2FLT4 | |
| SCHEMBL30505605 | 0.83 | EGFR (1.00) | KDREPHB4EGFRERBB2FLT4 | |
| Hydrochloric Acid SCHEMBL27887194 | 0.82 | EGFR (0.98) | KDREPHB4EGFRERBB2FLT4 | |
| SCHEMBL1225064 | 0.82 | EPHA2 (0.87) | KDREPHB4EPHA2ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892799-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-08-22 | — | — | EP | claimed |
| US-5770603-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1998-06-23 | — | — | US | claimed |
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| EP-0892799-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-08-22 | — | — | EP | disclosed |
| EP-0892799-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1999-01-27 | — | — | EP | disclosed |
| US-5770603-A | ANTICARCINOGENIC AGENTS | ZENECA LIMITED (GB) | 1998-06-23 | — | — | US | disclosed |
| WO-1997038994-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-10-23 | — | — | WO | disclosed |