SCHEMBL453290

SCHEMBL453290

Cc1ccc(NCC(N)=O)cc1O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.51
CYP1A2 P05177 2/20 0.50
CYP2D6 P10635 2/20 0.50
CYP2C9 P11712 2/20 0.50
CYP2C19 P33261 2/20 0.50
GAA P10253 2/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
CYP3A4 P08684 1/20 0.50
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
TUBA3C P0DPH7 1/20 0.44
TUBA1B P68363 1/20 0.44
TUBA4A P68366 1/20 0.44
TUBB4B P68371 1/20 0.44
TUBB3 Q13509 1/20 0.44
TUBB2A Q13885 1/20 0.44
TUBB8 Q3ZCM7 1/20 0.44
TUBA3E Q6PEY2 1/20 0.44
TUBA1A Q71U36 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29938824 1.00 ALDH1A1 (0.51) ALDH1A1CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6006586 0.90 SYK (0.48) ALDH1A1CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL5715031 0.89 ALDH1A1 (0.52) ALDH1A1CYP1A2CYP2D6CYP2C9CYP2C19
3-Aminophenol SCHEMBL6946895 0.86 ALDH1A1 (0.44) ALDH1A1CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL4574261 0.86 USP2 (0.55) ALDH1A1GAAMEN1KMT2ALMNA
SCHEMBL23804831 0.85 ALDH1A1 (0.40) ALDH1A1CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL15933411 0.84 ALDH1A1 (0.53) ALDH1A1CYP1A2CYP2D6CYP2C9CYP2C19
SCHEMBL6906254 0.84 ERCC1 (0.54) ALDH1A1MAPTALOX15TDP1ERCC1
SCHEMBL6387979 0.80 TSHR (0.49) ALDH1A1CYP1A2MEN1KMT2AMAPT
SCHEMBL16302258 0.78 CA12 (0.42) ALDH1A1GAAMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 548 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3096735-A1 GRADUAL HAIRCOLOR COMPOSITIONS AND METHODS OF USING THE SAME Combe International Ltd. (US) 2016-11-30 EP claimed
WO-2015112789-A1 GRADUAL HAIRCOLOR COMPOSITIONS AND METHODS OF USING THE SAME COMBE INTERNATIONAL LTD. (US) 2015-07-30 WO claimed
US-7066968-B2 Efficient two-step method of coloring and lightening hair with less damage UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. (US) 2006-06-27 US claimed
US-20050193501-A1 Efficient two-step method of coloring and lightening hair with less damage UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2005-09-08 US claimed
US-6821302-B2 Oxidation color dye comprising a metal cyanate, free of ammonia, without the pungent odor of ammonia UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-11-23 US claimed
US-6758867-B2 MIXTURE OF OXIDATION COLOR DYE, SHAMPOO AND CONDITIONER UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-07-06 US claimed
US-6743264-B2 DYEING USING MIXTURES OF OXIDATION COLOR DYE CHEMICAL INTERMEDIATES, HAIR CONDITIONERS AND OXIDIZERS IN SHAMPOOS, THEN RINSING WITH WATER UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-06-01 US claimed
US-6743265-B2 NUMBER OF TREATMENTS, HAVING A SET TIME INTERVAL BETWEEN EACH TWO CONSECUTIVE SUCH TREATMENTS; GELLING AGENT UNILEVER HOME & PERSONAL CARE USA DIVISION OF CONOPCO, INC. 2004-06-01 US claimed
US-20040098814-A1 Method and composition for the gradual permanent coloring of hair which employ carbonates UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-05-27 US claimed
US-6736861-B2 HAIR COLORING HAVING A SET TIME INTERVAL BETWEEN TWO CONSECUTIVE TREATMENTS, REPEAT THE SAME CONSECUTIVE TREATMENTS ABOUT 2 TO 30 TIMES UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. 2004-05-18 US claimed
WO-2002074266-A2 METHOD AND COMPOSITION FOR THE GRADUAL PERMANENT COLORING OF HAIR UNILEVER PLC (GB) 2002-09-26 WO claimed
EP-0853471-B1 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES, AND DYEING METHOD USING SAME OREAL (FR) 2001-10-31 EP claimed
US-6004356-A HAIR DYES L'OREAL (FR) 1999-12-21 US claimed
EP-0853471-A1 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES, AND DYEING METHOD USING SAME L'OREAL (FR) 1998-07-22 EP claimed
US-5735909-A Compositions and processes for the oxidation dyeing of keratin fibres with an oxidation base, a meta-aminophenol coupler, and a 6-hydroxyindoline coupler L'OREAL (FR) 1998-04-07 US claimed
WO-1997011674-A1 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES, AND DYEING METHOD USING SAME L'OREAL (FR) 1997-04-03 WO claimed
EP-0728465-B1 Composition for dyeing keratinous fibers comprising a meta-aminophenol and 6-hydroxyindoline, and dyeing process using such a composition OREAL (FR) 1997-03-19 EP claimed
EP-0728465-A1 Composition for dyeing keratinous fibers comprising a meta-aminophenol and 6-hydroxyindoline, and dyeing process using such a composition L'OREAL (FR) 1996-08-28 EP claimed
US-4324553-A OXIDATION COLOR DYES L'OREAL (FR) 1982-04-13 US claimed
US-4094635-A Meta-aminophenol sulfonamides as couplers in hair dye compositions L'OREAL (FR) 1978-06-13 US claimed