Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM4B | O94953 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.33 |
| ▸ | ECE1 | P42892 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169512 | 0.82 | — | — | |
| SCHEMBL31504724 | 0.80 | — | — | |
| SCHEMBL248687 | 0.80 | — | — | |
| SCHEMBL166576 | 0.80 | — | — | |
| SCHEMBL247550 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL5744190 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL5008231 | 0.78 | KDM4E (0.59) | KDM4EMAP3K5ALDH1A1TSHRPIM1 | |
| SCHEMBL13602604 | 0.78 | KDM4E (0.48) | KDM4EALDH1A1KDM4AKDM4BKDM5C | |
| SCHEMBL15334613 | 0.77 | KDM4E (0.57) | KDM4EMAP3K5ALDH1A1TSHRPIM1 | |
| SCHEMBL11167638 | 0.75 | KDM4E (0.61) | KDM4EMAP3K5ALDH1A1TSHRPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109923108-A | Pyridyl-substituted indole compounds | 百时美施贵宝公司 | 2019-06-21 | — | — | CN | claimed |
| CN-109761976-A | The condensed Azadecalin glucocorticoid receptor modulators of octahydro | 科赛普特治疗公司 | 2019-05-17 | — | — | CN | claimed |
| CN-106029066-B | Octahydro fused azadecalin glucocorticoid receptor modulators | 科赛普特治疗公司 | 2019-03-15 | — | — | CN | claimed |
| CN-104619328-B | The condensed quinoline alkane glucocorticoid receptor modulator of heteroaryl -one | 科赛普特治疗学股份有限公司 | 2018-10-02 | — | — | CN | claimed |
| CN-106029066-A | Octahydro fused azadecalin glucocorticoid receptor modulators | 科赛普特治疗公司 | 2016-10-12 | — | — | CN | claimed |
| CN-104619328-A | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators | CORCEPT THERAPEUTICS INC | 2015-05-13 | — | — | CN | claimed |
| JP-4294903-B2 | — | — | 2009-07-15 | — | — | JP | claimed |
| JP-2003519135-A | — | — | 2003-06-17 | — | — | JP | claimed |
| US-6458787-B1 | NOVEL PYRROLIDINE COMPOUNDS THAT ARE POTENT AND SELECTIVE INHIBITORS OF PDE4, AS WELL AS METHODS OF MAKING THE SAME, ARE DISCLOSED. USE OF THE COMPOUNDS IN THE TREATMENT OF INFLAMMATORY DISEASES AND OTHER DISEASES INVOLVING ELEVATED | ICOS CORPORATION | 2002-10-01 | — | — | US | claimed |
| EP-1242400-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2002-09-25 | — | — | EP | claimed |
| WO-2001047905-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2001-07-05 | — | — | WO | claimed |
| CN-106459083-B | Amide derivatives with the active 1- oxa- -4,9- diaza spiro hendecane compound of the anti-pain of multiplex mode | 埃斯蒂文制药股份有限公司 | 2019-10-01 | — | — | CN | disclosed |
| CN-110177553-A | Alkyl Pyrrolopyrimidine is like object and its preparation and application | 北卡罗来纳大学教堂山分校 | 2019-08-27 | — | — | CN | disclosed |
| CN-109923108-A | Pyridyl-substituted indole compounds | 百时美施贵宝公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-109761976-A | The condensed Azadecalin glucocorticoid receptor modulators of octahydro | 科赛普特治疗公司 | 2019-05-17 | — | — | CN | disclosed |
| CN-1662531-A | bicyclic heterocyclic compounds | KYOWA HAKKO KOGYO KK (JP) | 2005-08-31 | — | — | CN | disclosed |
| CN-1434813-A | Pyrrolidine derivatives cyclic AMP-specific phosphodiesterase inhibitors | ICOS CONP (US) | 2003-08-06 | — | — | CN | disclosed |
| US-6458787-B1 | NOVEL PYRROLIDINE COMPOUNDS THAT ARE POTENT AND SELECTIVE INHIBITORS OF PDE4, AS WELL AS METHODS OF MAKING THE SAME, ARE DISCLOSED. USE OF THE COMPOUNDS IN THE TREATMENT OF INFLAMMATORY DISEASES AND OTHER DISEASES INVOLVING ELEVATED | ICOS CORPORATION | 2002-10-01 | — | — | US | disclosed |
| EP-1242400-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001047905-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2001-07-05 | — | — | WO | disclosed |