Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 10/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537298 | 0.97 | EPHX2 (0.49) | EPHX2HRH3P2RX7ALDH1A1CYP2C9 | |
| SCHEMBL4541187 | 0.87 | KDM4E (0.50) | HRH3ALDH1A1 | |
| SCHEMBL4542903 | 0.87 | EPHX2 (0.48) | EPHX2HRH3P2RX7ALDH1A1CYP2C9 | |
| SCHEMBL4537464 | 0.84 | EPHX2 (0.51) | EPHX2HRH3P2RX7ALDH1A1CYP2C9 | |
| SCHEMBL4538182 | 0.84 | USP30 (0.47) | HRH3ALDH1A1 | |
| SCHEMBL4535382 | 0.83 | EPHX2 (0.59) | EPHX2CYP2C9CYP2J2 | |
| SCHEMBL4542312 | 0.81 | EPHX2 (0.61) | EPHX2CYP2C9CYP2J2 | |
| SCHEMBL4531270 | 0.81 | EPHX2 (0.68) | EPHX2CYP2C9CYP2J2 | |
| SCHEMBL4533493 | 0.80 | ALDH1A1 (0.48) | EPHX2HRH3P2RX7ALDH1A1CYP2C9 | |
| SCHEMBL4542900 | 0.80 | EPHX2 (0.47) | EPHX2HRH3P2RX7ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |