Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10742507 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2NOS1ADAMTS5PDE10AFDPS | |
| SCHEMBL19072060 | 0.75 | RAB9A (0.39) | SMN1; SMN2NOS1ADAMTS5FDPSNPC1 | |
| SCHEMBL3934510 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2NOS1ADAMTS5PDE10AFDPS | |
| SCHEMBL634118 | 0.71 | — | — | |
| SCHEMBL2041379 | 0.70 | SMN1; SMN2 (0.44) | SMN1; SMN2NOS1ADAMTS5PDE10ANPC1 | |
| SCHEMBL344952 | 0.70 | — | — | |
| Hydrochloric Acid SCHEMBL17871683 | 0.69 | SMN1; SMN2 (0.40) | SMN1; SMN2NOS1ADAMTS5PDE10AFDPS | |
| Bromide SCHEMBL9811452 | 0.69 | SMN1; SMN2 (0.40) | SMN1; SMN2NOS1ADAMTS5PDE10AFDPS | |
| SCHEMBL19590951 | 0.69 | SMN1; SMN2 (0.48) | SMN1; SMN2NOS1ADAMTS5PDE10ANPC1 | |
| Hydrochloric Acid SCHEMBL2029121 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012064269-A1 | COMPOUNDS AND THEIR USE FOR TREATMENT OF Αβ-RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-05-18 | — | — | WO | disclosed |