Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539216 | 0.84 | HDAC1 (0.72) | HDAC1HDAC2HDAC3CYP2C9SLC6A4 | |
| SCHEMBL4535217 | 0.84 | HDAC1 (0.72) | HDAC1HDAC2HDAC3CYP2C9SLC6A4 | |
| SCHEMBL4534468 | 0.81 | HDAC2 (0.67) | HDAC1HDAC2HDAC3 | |
| SCHEMBL5135178 | 0.81 | HDAC1 (0.51) | HDAC1HDAC2HDAC3HDAC10HDAC6 | |
| SCHEMBL1639843 | 0.77 | HDAC1 (0.57) | HDAC1HDAC2HDAC3 | |
| SCHEMBL4534973 | 0.76 | HDAC1 (0.74) | HDAC1HDAC2HDAC3CYP2C9SLC6A4 | |
| SCHEMBL14312435 | 0.76 | HDAC1 (0.50) | HDAC1HDAC2HDAC3CYP2C9SLC6A4 | |
| SCHEMBL8244745 | 0.75 | HDAC1 (0.61) | HDAC1HDAC2HDAC3CYP2C9SLC6A4 | |
| SCHEMBL2438521 | 0.75 | HDAC1 (0.53) | HDAC1HDAC2HDAC3HDAC10HDAC6 | |
| SCHEMBL4532581 | 0.74 | HDAC1 (0.57) | HDAC1HDAC2HDAC3CYP2C9SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105264-A1 | Substituted Nicotinamide Compounds | MERCK SHARP & DOHME CORP. | 2009-04-23 | — | — | US | claimed |
| US-20090105264-A1 | Substituted Nicotinamide Compounds | MERCK SHARP & DOHME CORP. | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105264-A1 | Substituted Nicotinamide Compounds | SIRT1, NQO1, TXNRD2 | HDAC1 15/4885HDAC2 17/4885HDAC3 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.