Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4337577 | 0.91 | MAPT (0.50) | MAPTPIK3CDKMT2AMEN1LMNA | |
| SCHEMBL4635644 | 0.84 | PIK3CG (0.45) | MAPTPIK3CDTP53 | |
| SCHEMBL4339120 | 0.82 | PIK3CG (0.51) | MAPTPIK3CDTP53 | |
| SCHEMBL4351831 | 0.82 | MEN1 (0.47) | MAPTPIK3CDKMT2AMEN1NPC1 | |
| SCHEMBL4341730 | 0.79 | PIK3CD (0.49) | MAPTPIK3CDKMT2AMEN1LMNA | |
| SCHEMBL4481357 | 0.78 | MAPT (0.50) | MAPTKMT2AMEN1NPC1TP53 | |
| SCHEMBL189032 | 0.77 | MAPT (0.73) | MAPTPIK3CDKMT2AMEN1ALDH1A1 | |
| SCHEMBL3690864 | 0.77 | PIK3CG (0.50) | MAPTPIK3CDTP53 | |
| SCHEMBL4636003 | 0.76 | PIK3CA (0.56) | MAPTPIK3CDKMT2AMEN1LMNA | |
| SCHEMBL27901645 | 0.75 | PIK3CD (0.56) | MAPTPIK3CDKMT2AMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012065057-A2 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS AND METHODS OF THEIR USE | EXELIXIS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |
| EP-1931645-A2 | N- (3-AMINO-QUINOXALIN-2-YL) -SULFONAMIDE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Exelixis, Inc. (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007044729-A2 | N- (3-AMINO-QUINOXALIN-2-YL) -SULFONAMIDE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | EXELIXIS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |