Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 14/20 | 0.68 |
| ▸ | HCRTR2 | O43614 | 13/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CRHBP | P24387 | 2/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538669 | 0.81 | HCRTR1 (1.00) | HCRTR1HCRTR2 | |
| SCHEMBL745939 | 0.73 | HCRTR2 (0.68) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL4542056 | 0.69 | HCRTR1 (0.70) | HCRTR1HCRTR2SMN1; SMN2CRHBPCRHR2 | |
| SCHEMBL16480155 | 0.67 | HRH3 (0.53) | HCRTR1HCRTR2 | |
| SCHEMBL4541256 | 0.65 | HCRTR1 (1.00) | HCRTR1HCRTR2 | |
| SCHEMBL28804889 | 0.65 | HCRTR1 (0.66) | HCRTR1HCRTR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL4559363 | 0.65 | HCRTR1 (0.72) | HCRTR1HCRTR2 | |
| SCHEMBL6332041 | 0.64 | FAAH (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL16477331 | 0.64 | MCHR1 (0.50) | HCRTR1HCRTR2MAPT | |
| Hydrochloric Acid SCHEMBL6329363 | 0.63 | FAAH (0.51) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638008-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012063207-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-05-18 | — | — | WO | disclosed |