Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5213662 | 0.81 | POLB (0.50) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7030997 | 0.80 | POLB (0.49) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL11195887 | 0.76 | ALDH1A1 (0.45) | POLBALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL2006539 | 0.75 | POLB (0.66) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL9105524 | 0.75 | POLB (0.75) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL9365631 | 0.74 | POLB (0.47) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL9366498 | 0.73 | POLB (0.46) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL9365505 | 0.73 | POLB (0.46) | POLBALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL14357462 | 0.73 | POLB (0.49) | POLBALDH1A1MAPTSMN1; SMN2GAA | |
| SCHEMBL4540943 | 0.72 | ALDH1A1 (0.62) | ALDH1A1MAPTSMN1; SMN2LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |