Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 18/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 16/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539568 | 0.93 | EPHX1 (0.68) | EPHX1EPHX2 | |
| SCHEMBL4542890 | 0.84 | EPHX1 (0.53) | EPHX1EPHX2KDM4E | |
| SCHEMBL4535568 | 0.79 | EPHX2 (0.64) | EPHX1EPHX2 | |
| SCHEMBL12196135 | 0.78 | EPHX1 (1.00) | EPHX1EPHX2 | |
| SCHEMBL4537216 | 0.78 | EPHX2 (0.67) | EPHX1EPHX2 | |
| SCHEMBL4539332 | 0.78 | EPHX2 (0.67) | EPHX1EPHX2 | |
| SCHEMBL4540420 | 0.76 | EPHX1 (0.63) | EPHX1EPHX2 | |
| SCHEMBL652237 | 0.76 | EPHX1 (1.00) | EPHX1EPHX2 | |
| SCHEMBL8064706 | 0.75 | EPHX2 (0.61) | EPHX1EPHX2 | |
| SCHEMBL4537103 | 0.75 | KDM4E (0.54) | EPHX1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |