Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539572 | 0.93 | KDM4E (0.53) | KDM4EEPHX1HTTMEN1KMT2A | |
| SCHEMBL4535571 | 0.81 | LMNA (0.40) | HTTMEN1KMT2ALMNAPKM | |
| SCHEMBL4537217 | 0.81 | BRD4 (0.55) | KDM4EEPHX1HTTGAALMNA | |
| SCHEMBL4539333 | 0.80 | KMT2A (0.56) | EPHX1MEN1KMT2AGAALMNA | |
| SCHEMBL4541042 | 0.78 | FAAH (0.53) | KDM4EMEN1KMT2AGAAHSD17B10 | |
| SCHEMBL4542442 | 0.76 | BRD4 (0.44) | KDM4EEPHX1KMT2ALMNAPOLB | |
| SCHEMBL4531024 | 0.76 | MEN1 (0.55) | KDM4EHTTMEN1KMT2AGAA | |
| SCHEMBL4542474 | 0.76 | USP30 (0.58) | KDM4EHTTMEN1KMT2ALMNA | |
| SCHEMBL4540424 | 0.75 | ALDH1A1 (0.42) | EPHX1ALDH1A1MAPT | |
| SCHEMBL4537100 | 0.75 | EPHX1 (0.62) | KDM4EEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |