Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 19/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.51 |
| ▸ | CYP2J2 | P51589 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539592 | 0.95 | EPHX2 (0.70) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL4531022 | 0.94 | EPHX2 (0.61) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL4542312 | 0.87 | EPHX2 (0.61) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL4531270 | 0.82 | EPHX2 (0.68) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL4537421 | 0.82 | EPHX2 (0.59) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL4537464 | 0.82 | EPHX2 (0.51) | EPHX2CYP2C9CYP2J2 | |
| SCHEMBL4542903 | 0.81 | EPHX2 (0.48) | EPHX2CYP2C9CYP2J2 | |
| SCHEMBL4537571 | 0.81 | NPC1 (0.52) | EPHX2 | |
| SCHEMBL4535382 | 0.81 | EPHX2 (0.59) | EPHX2CYP2C9CYP2J2CYP2C19 | |
| SCHEMBL4539590 | 0.79 | EPHX2 (0.68) | EPHX2CYP2C9CYP2J2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |