Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537172 | 0.88 | USP30 (0.55) | NPC1EPHX2USP30KMT2ASMN1; SMN2 | |
| SCHEMBL4539592 | 0.86 | EPHX2 (0.70) | EPHX2KMT2A | |
| SCHEMBL4537568 | 0.83 | P2RX7 (0.50) | NPC1EPHX2USP30KMT2ASMN1; SMN2 | |
| SCHEMBL4542474 | 0.83 | USP30 (0.58) | NPC1EPHX2USP30KMT2ASMN1; SMN2 | |
| SCHEMBL4537424 | 0.81 | EPHX2 (0.63) | EPHX2 | |
| SCHEMBL8064542 | 0.79 | USP30 (0.48) | NPC1EPHX2USP30KMT2ASMN1; SMN2 | |
| SCHEMBL4537166 | 0.78 | USP30 (0.50) | NPC1EPHX2USP30SMN1; SMN2L3MBTL1 | |
| SCHEMBL4537314 | 0.77 | POLB (0.44) | EPHX2USP30KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL4543058 | 0.77 | USP30 (0.55) | EPHX2USP30KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4531270 | 0.75 | EPHX2 (0.68) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |