Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.33 |
| ▸ | STK4 | Q13043 | 1/20 | 0.33 |
| ▸ | STK3 | Q13188 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 4/20 | 0.33 |
| ▸ | CCR4 | P51679 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4534782 | 0.91 | BTK (0.38) | KMT2ALRRK2STK4STK3BTK | |
| SCHEMBL4530994 | 0.87 | CYP1A2 (0.37) | KDM4EKMT2ABTKAURKARPS6KB1 | |
| SCHEMBL3701506 | 0.81 | PIK3CD (0.40) | KDM4EKMT2APIK3CDABCB11TBXA2R | |
| SCHEMBL3701510 | 0.81 | PIK3CD (0.40) | KDM4EKMT2APIK3CDABCB11TBXA2R | |
| SCHEMBL4531006 | 0.77 | SGK1 (0.33) | PIK3CDABCB11TBXA2RPIK3R1HTR2A | |
| SCHEMBL291170 | 0.74 | HTT (0.34) | PIK3CDPIK3R1PIK3CAHTTSMN1; SMN2 | |
| SCHEMBL3702416 | 0.73 | PIK3CD (0.42) | BTKPIK3CDABCB11TBXA2RPIK3R1 | |
| SCHEMBL3702405 | 0.73 | PIK3CD (0.42) | BTKPIK3CDABCB11TBXA2RPIK3R1 | |
| SCHEMBL4572211 | 0.72 | PIK3CD (0.40) | PIK3CDABCB11TBXA2RPIK3R1HTR2A | |
| SCHEMBL935671 | 0.70 | PIK3CD (0.51) | PIK3CDABCB11TBXA2RPIK3R1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637669-A2 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | Infinity Pharmaceuticals, Inc. (US) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064973-A2 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS, INC. (US) | 2012-05-18 | — | — | WO | disclosed |