SCHEMBL935671

SCHEMBL935671

O=c1c2c(Cl)cccc2cc(CCNc2ncnc3[nH]cnc23)n1-c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 20/20 0.51
PIK3R1 P27986 14/20 0.51
PIK3CG P48736 13/20 0.51
PIK3CA P42336 7/20 0.51
PIK3CB P42338 7/20 0.51
ABCB11 O95342 1/20 0.51
TBXA2R P21731 1/20 0.51
HTR2A P28223 1/20 0.51
PDE3A Q14432 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL935884 0.89 PIK3R1 (0.44) PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB
SCHEMBL2599465 0.89 PIK3CD (0.41) PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB
SCHEMBL2599467 0.87 PIK3CD (0.39) PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB
SCHEMBL16671078 0.84 PIK3CD (0.43) PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB
SCHEMBL14993340 0.84 PIK3CD (0.51) PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB
SCHEMBL935387 0.83 PIK3CD (0.43) PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB
SCHEMBL5607774 0.81 PIK3CD (0.49) PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB
SCHEMBL936006 0.81 PIK3CD (0.39) PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB
SCHEMBL935803 0.80 PIK3R1 (0.46) PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB
SCHEMBL9924638 0.80 PIK3R1 (0.45) PIK3CDPIK3R1PIK3CGPIK3CAPIK3CB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4561704-A2 USE OF GLYCOGEN METABOLISM INHIBITORS FOR THE TREATMENT OF CANCER The University Of Vermont (US) 2025-06-04 EP claimed
WO-2024026458-A2 USE OF GLYCOGEN METABOLISM INHIBITORS FOR THE TREATMENT OF CANCER THE UNIVERSITY OF VERMONT (US) 2024-02-01 WO claimed
EP-4110344-A2 USE OF THYROMIMETICS FOR THE TREATMENT OF CANCER The University Of Vermont (US) 2023-01-04 EP claimed
EP-3074016-A2 THERAPIES FOR TREATING MYELOPROLIFERATIVE DISORDERS Gilead Sciences, Inc. (US) 2016-10-05 EP claimed
WO-2015160986-A2 COMBINATION THERAPIES INFINITY PHARMACEUTICALS, INC. (US) 2015-10-22 WO claimed
WO-2015160975-A2 COMBINATION THERAPIES INFINITY PHARMACEUTICALS, INC. (US) 2015-10-22 WO claimed
EP-2916868-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A PI3 DELTA OR DUAL PI3 DELTA-GAMMA KINASE INHIBITOR Rhizen Pharmaceuticals S.A. (CH) 2015-09-16 EP claimed
WO-2015081127-A2 THERAPIES FOR TREATING MYELOPROLIFERATIVE DISORDERS GILEAD SCIENCES, INC. (US) 2015-06-04 WO claimed
WO-2014072937-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A PI3 DELTA OR DUAL PI3 DELTA-GAMMA KINASE INHIBITOR RHIZEN PHARMACEUTICALS SA (CH) 2014-05-15 WO claimed
EP-4731199-A2 COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING COLORECTAL CANCER Burzynski, Stanislaw R. (US) 2026-04-29 EP disclosed
EP-4731792-A2 COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING LUNG CANCER Burzynski, Stanislaw R. (US) 2026-04-29 EP disclosed
EP-4727534-A1 COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING BREAST CANCER Burzynski, Stanislaw R. (US) 2026-04-22 EP disclosed
WO-2024263972-A2 COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING UNCOMMON CANCERS BURZYNSKI STANISLAW R (US) 2024-12-26 WO disclosed
WO-2024263643-A1 COMPOSITIONS COMPRISING ANTINEOPLASTONS AND METHODS OF TREATING BREAST CANCER BURZYNSKI STANISLAW R (US) 2024-12-26 WO disclosed
EP-2663309-A1 PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES Infinity Pharmaceuticals, Inc. (US) 2013-11-20 EP disclosed
EP-2571357-A1 CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION Intellikine, Inc. (US) 2013-03-27 EP disclosed
WO-2012097000-A1 PROCESSES FOR PREPARING ISOQUINOLINONES AND SOLID FORMS OF ISOQUINOLINONES REN PINGDA (US) 2012-07-19 WO disclosed
EP-2456444-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS Intellikine, Inc. (US) 2012-05-30 EP disclosed
WO-2011146882-A1 CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION INTELLIKINE, INC. (US) 2011-11-24 WO disclosed
WO-2011008302-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS INTELLIKINE, INC. (US) 2011-01-20 WO disclosed