Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 17/20 | 0.54 |
| ▸ | HCRTR2 | O43614 | 17/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11100815 | 0.94 | CHRM5 (0.56) | HCRTR1HCRTR2CHRM5ALDH1A1TSHR | |
| SCHEMBL30767534 | 0.79 | GCGR (0.48) | HCRTR1HCRTR2CHRM5 | |
| SCHEMBL40778 | 0.79 | CMA1 (0.66) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL7952768 | 0.78 | CA1 (0.51) | HCRTR1HCRTR2CHRM5ALDH1A1TSHR | |
| SCHEMBL2097565 | 0.76 | CHRM5 (0.52) | CHRM5ALDH1A1 | |
| SCHEMBL19233352 | 0.76 | KMT2A (0.69) | HCRTR1HCRTR2ALDH1A1TSHR | |
| SCHEMBL745994 | 0.76 | CHRM5 (0.48) | HCRTR1HCRTR2CHRM5ALDH1A1TSHR | |
| SCHEMBL2056195 | 0.76 | CHRM5 (0.51) | HCRTR1HCRTR2CHRM5ALDH1A1 | |
| SCHEMBL12625981 | 0.75 | ALDH1A1 (0.66) | CHRM5ALDH1A1TSHR | |
| SCHEMBL9677874 | 0.75 | CHRM5 (0.60) | HCRTR1HCRTR2CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242970-B2 | Lactam derivatives useful as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-01-26 | — | — | US | disclosed |
| EP-2638008-B1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-07-01 | — | — | EP | disclosed |
| EP-2638008-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2013-09-18 | — | — | EP | disclosed |
| US-20130237525-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-09-12 | — | — | US | disclosed |
| WO-2012063207-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130237525-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY1R | HCRTR1 2/4885HCRTR2 1/4885CHRM5 218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.