Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.68 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.63 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.60 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | KDM5A | P29375 | 1/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.51 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4562037 | 0.94 | MAPK14 (0.68) | MAPK14NR3C2MAPK13MAPK12MAPK11 | |
| SCHEMBL4539819 | 0.83 | MAPK14 (0.68) | MAPK14NR3C2MAPK13MAPK12MAPK11 | |
| SCHEMBL27335372 | 0.81 | MAPK14 (1.00) | MAPK14NR3C2MAPK13MAPK12MAPK11 | |
| SCHEMBL4537652 | 0.78 | NR3C2 (1.00) | MAPK14NR3C2MAPK13MAPK12MAPK11 | |
| SCHEMBL4561720 | 0.78 | MAPK14 (0.68) | MAPK14NR3C2MAPK13MAPK12MAPK11 | |
| SCHEMBL20550774 | 0.77 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL29676815 | 0.76 | MAPK14 (0.61) | MAPK14NR3C2MAPK13MAPK12MAPK11 | |
| SCHEMBL18041561 | 0.76 | MAPK14 (0.61) | MAPK14NR3C2MAPK13MAPK12MAPK11 | |
| SCHEMBL2849517 | 0.76 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11PDE4A | |
| SCHEMBL23410259 | 0.75 | MAPK14 (0.58) | MAPK14NR3C2MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8722709-B2 | Mineralocorticoid receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-13 | — | — | US | disclosed |
| US-8722709-B2 | Mineralocorticoid receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-13 | — | — | US | disclosed |
| US-8722709-B2 | Mineralocorticoid receptor antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-05-13 | — | — | US | disclosed |
| EP-2638012-A1 | PYRIDYL UREAS AS MINERALOCORTICOID RECEPTOR ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2013-09-18 | — | — | EP | disclosed |
| US-20120289551-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2012-11-15 | — | — | US | disclosed |
| US-20120289551-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2012-11-15 | — | — | US | disclosed |
| US-20120289551-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH | 2012-11-15 | — | — | US | disclosed |
| WO-2012064631-A1 | PYRIDYL UREAS AS MINERALOCORTICOID RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289551-A1 | MINERALOCORTICOID RECEPTOR ANTAGONISTS | NR3C2, MC2R, AVPR2 | MAPK14 1484/4885NR3C2 1/4885MAPK13 1013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.