MC2R — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL21700464	1.00	20/20
SCHEMBL21700468	1.00	20/20
SCHEMBL21700474	1.00	20/20
SCHEMBL21700537	1.00	20/20
SCHEMBL21700566	1.00	20/20
SCHEMBL21700593	1.00	20/20
SCHEMBL21700598	1.00	20/20
SCHEMBL21700646	1.00	20/20
SCHEMBL21700807	1.00	20/20
SCHEMBL21700809	1.00	20/20
SCHEMBL21725661	1.00	20/20
SCHEMBL21860083	1.00	20/20
Acetic Acid (SCHEMBL21700533)	0.96	20/20
SCHEMBL21700508	0.93	20/20
SCHEMBL21700546	0.91	20/20
SCHEMBL21700731	0.90	20/20
SCHEMBL21700618	0.89	20/20
SCHEMBL21701006	0.88	20/20
SCHEMBL21700475	0.88	20/20
SCHEMBL21700931	0.87	20/20

Clinical trials — most relevant to MC2R by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of H.P. Acthar Gel for the Treatment of Refractory Cutaneous Manifestations of Dermatomyositis	PHASE4	COMPLETED
Acthar Gel for Chronic Pulmonary Sarcoidosis (ACPS)	PHASE4	UNKNOWN
Efficacy, Radiographic and Laboratory Changes in Refractory Rheumatoid Arthritis Patients Treated With H.P. Acthar Gel	PHASE4	UNKNOWN
How DHEA Supplements Affect Coagulation in Women Using Birth Control Pills	PHASE4	COMPLETED
A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome	PHASE3	COMPLETED
Triple Therapy in Septic Shock Patients	PHASE3	COMPLETED
Effects of Acthar on Recovery From Cognitive Relapses in MS	PHASE3	COMPLETED
ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study)	PHASE2	COMPLETED
A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis	PHASE2	UNKNOWN
Novel Therapeutics in Posttraumatic Stress Disorder (PTSD): A Randomized Clinical Trial of Mifepristone	PHASE2	COMPLETED
Preoperative Bexarotene Treatment for Cushing's Disease	PHASE1/PHASE2	UNKNOWN
Fludrocortisone and Information Processing in Healthy Volunteers	PHASE1	COMPLETED
The Role of Minerelocorticoid Receptor on Modulating Aldosterone Production	PHASE1	COMPLETED
Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Study	EARLY_PHASE1	COMPLETED
Examination of Brain Serotonin Receptors in Patients With Mood Disorders	nan	COMPLETED
Overnight Dexamethasone in Primary Aldosteronism Screening	nan	RECRUITING
Availability Study of ACTH to Treat Children SRNS/SDNS	nan	UNKNOWN
Study of Adrenal Gland Tumors	nan	COMPLETED
Retrospective Evaluation of Melanocortin Receptor 4 Polymorphisms in Patients With GBM Treated With Radiochemotherapy	nan	COMPLETED
Modified Desmopressin (mDesmo) Using Cold-Kit for PET/CT	nan	RECRUITING
Does Intravitreal Injection of Triamcinolone Acetonide Impairs the Adrenal Function	nan	COMPLETED
Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency	nan	COMPLETED
Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder	nan	COMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
Study of Cushing's Syndrome Not Related to ACTH Production	nan	COMPLETED
Examining Genetic Differences Among People With 21-Hydroxylase Deficiency	nan	COMPLETED
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks	nan	RECRUITING
A Proof-of-concept Study Evaluating the Microbiota-gut-brain Axis	nan	RECRUITING
Neuroprotective Effects of ACTH4-10PRO8-GLY9-PRO10	nan	COMPLETED
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a MC2R binder may also engage these)

Protein	Name	Similarity
P70115	—	1.000	P70115 →
Q64326	—	1.000	Q64326 →
Q9TU77	—	1.000	Q9TU77 →
P34974	—	1.000	P34974 →
O97504	—	1.000	O97504 →
Q9Z1S9	—	1.000	Q9Z1S9 →
P35345	—	1.000	P35345 →
P70596	—	1.000	P70596 →
P33033	—	0.999	P33033 →
Q8HYN8	—	0.999	Q8HYN8 →
P32244	—	0.998	P32244 →
P56450	—	0.998	P56450 →
MC3R	Melanocortin receptor 3	0.997	landscape →
MC4R	Melanocortin receptor 4	0.997	landscape →
Q0Z8I9	—	0.997	Q0Z8I9 →
P41149	—	0.997	P41149 →
MC5R	Melanocortin receptor 5	0.996	landscape →
P56451	—	0.996	P56451 →
Q8HXX3	—	0.996	Q8HXX3 →
Q9GLJ8	—	0.995	Q9GLJ8 →
B0V1P1	—	0.993	B0V1P1 →
Q9MZV8	—	0.993	Q9MZV8 →
Q9TT23	—	0.986	Q9TT23 →
P41983	—	0.986	P41983 →
GPR52	G-protein coupled receptor 52	0.982	landscape →
Q8BX79	—	0.981	Q8BX79 →
Q80SS9	—	0.981	Q80SS9 →
P25102	—	0.980	P25102 →
P0C5J4	—	0.980	P0C5J4 →
Q01727	—	0.980	Q01727 →