Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 6/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1615895 | 1.00 | NPC1 (0.42) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL1616482 | 1.00 | NPC1 (0.42) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL1761914 | 0.88 | GABRA1 (0.44) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL1762204 | 0.88 | GABRA1 (0.44) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL1617313 | 0.87 | GABRA1 (0.42) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL1616031 | 0.86 | NPC1 (0.46) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL1617011 | 0.86 | NPC1 (0.46) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL1616776 | 0.84 | NPC1 (0.53) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL1616093 | 0.84 | NPC1 (0.53) | NPC1RAB9AGABRA1GABRG2GABRB3 | |
| SCHEMBL1617120 | 0.84 | NPC1 (0.53) | NPC1RAB9AGABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996556-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2009-11-18 | — | — | EP | disclosed |