Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4540905 | 0.82 | FASN (0.64) | FASNALDH1A1METAP2SMN1; SMN2LRRK2 | |
| SCHEMBL4536294 | 0.77 | FASN (0.56) | FASNALDH1A1SMN1; SMN2LRRK2MTOR | |
| SCHEMBL4540325 | 0.77 | FASN (0.55) | FASNALDH1A1KDM4EMETAP2SMN1; SMN2 | |
| SCHEMBL4541442 | 0.75 | FASN (0.76) | FASNALDH1A1SMN1; SMN2LRRK2MTOR | |
| SCHEMBL4539655 | 0.70 | FASN (0.62) | FASNALDH1A1KDM4EMETAP2SMN1; SMN2 | |
| SCHEMBL4543103 | 0.68 | FASN (0.73) | FASNALDH1A1METAP2SMN1; SMN2PKM | |
| SCHEMBL4539661 | 0.67 | FASN (0.76) | FASNALDH1A1CYP2D6SMN1; SMN2LRRK2 | |
| SCHEMBL4535806 | 0.66 | FASN (0.51) | FASNALDH1A1KDM4ESMN1; SMN2PKM | |
| SCHEMBL4541212 | 0.66 | FASN (0.55) | FASNALDH1A1KDM4ESMN1; SMN2LRRK2 | |
| SCHEMBL4541537 | 0.66 | FASN (0.54) | FASNALDH1A1KDM4ESMN1; SMN2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | disclosed |