Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 4/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561831 | 0.86 | FASN (0.46) | FASNALDH1A1KDM4EPKMMAPK1 | |
| SCHEMBL4538721 | 0.79 | FASN (0.79) | FASNALDH1A1KDM4EPKMMCOLN3 | |
| SCHEMBL4540739 | 0.78 | CNR1 (0.38) | FASNALDH1A1KDM4EPKML3MBTL1 | |
| SCHEMBL4538282 | 0.70 | FASN (0.76) | FASNALDH1A1PKMMAPK1MEN1 | |
| SCHEMBL22259570 | 0.70 | FASN (0.58) | FASNALDH1A1KDM4EPKMLMNA | |
| SCHEMBL4540780 | 0.69 | FASN (0.68) | FASNALDH1A1KDM4EPKMMAPK1 | |
| SCHEMBL4540099 | 0.69 | FASN (0.73) | FASNALDH1A1KDM4EPKMLMNA | |
| SCHEMBL4536291 | 0.68 | MGLL (0.48) | FASNALDH1A1KDM4EPKMMAPK1 | |
| SCHEMBL30754647 | 0.68 | PKM (0.78) | ALDH1A1PKMMCOLN3LMNATSHR | |
| SCHEMBL4543035 | 0.68 | FASN (1.00) | FASNALDH1A1KDM4ELMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637660-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012064642-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2012-05-18 | — | — | WO | disclosed |