Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4539130 | 0.94 | KCNA5 (1.00) | KCNA5 | |
| SCHEMBL14615175 | 0.90 | KCNA5 (0.81) | KCNA5 | |
| SCHEMBL4530400 | 0.87 | KCNA5 (0.77) | KCNA5 | |
| SCHEMBL4530959 | 0.86 | KCNA5 (0.75) | KCNA5 | |
| SCHEMBL4540557 | 0.85 | KCNA5 (1.00) | KCNA5 | |
| SCHEMBL4537461 | 0.84 | KCNA5 (0.78) | KCNA5 | |
| SCHEMBL4541870 | 0.84 | KCNA5 (0.77) | KCNA5 | |
| SCHEMBL14615334 | 0.84 | KCNA5 (0.78) | KCNA5 | |
| SCHEMBL4539054 | 0.84 | KCNA5 (1.00) | KCNA5 | |
| SCHEMBL4533836 | 0.83 | KCNA5 (1.00) | KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278317-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-10-02 | — | — | US | claimed |
| US-20090124665-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-05-14 | — | — | US | claimed |
| US-8278317-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278317-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278317-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-10-02 | — | — | US | disclosed |
| US-20090124665-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-05-14 | — | — | US | disclosed |
| US-20090124665-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-05-14 | — | — | US | disclosed |
| US-20090124665-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124665-A1 | Potassium Channel Inhibitors | KCNJ2, KCNH2, KCNH3 | KCNA5 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.