Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.54 |
| ▸ | EPHX1 | P07099 | 13/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 13/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541793 | 0.97 | HSD11B1 (0.52) | HSD11B1EPHX1EPHX2 | |
| SCHEMBL8063666 | 0.97 | HSD11B1 (0.52) | HSD11B1EPHX1EPHX2 | |
| SCHEMBL4534763 | 0.91 | EPHX1 (0.52) | HSD11B1EPHX1EPHX2 | |
| SCHEMBL4537063 | 0.88 | EPHX2 (0.52) | EPHX1EPHX2 | |
| SCHEMBL8067423 | 0.88 | EPHX2 (0.52) | EPHX1EPHX2 | |
| SCHEMBL4534331 | 0.88 | HSD11B1 (0.57) | HSD11B1EPHX1EPHX2 | |
| SCHEMBL8061501 | 0.87 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL4539750 | 0.85 | HSD11B1 (0.52) | HSD11B1 | |
| SCHEMBL4539759 | 0.85 | HSD11B1 (0.58) | HSD11B1EPHX1EPHX2 | |
| SCHEMBL4542937 | 0.84 | EPHX2 (0.57) | HSD11B1EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |