Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4999656 | 1.00 | HDAC1 (0.61) | HDAC1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL4540403 | 0.92 | HDAC1 (0.53) | HDAC1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL4990054 | 0.92 | HDAC1 (0.53) | HDAC1KMT2AALDH1A1KDM4EMAPK1 | |
| SCHEMBL4999726 | 0.89 | TSHR (0.55) | HDAC1ALDH1A1LMNAKDM4EMAPK1 | |
| SCHEMBL4542218 | 0.89 | TSHR (0.55) | HDAC1ALDH1A1LMNAKDM4EMAPK1 | |
| SCHEMBL3879826 | 0.86 | GRM4 (0.48) | HDAC1ALDH1A1KDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL311727 | 0.86 | GRM4 (0.48) | HDAC1ALDH1A1KDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL4999677 | 0.85 | MDM4 (0.50) | HDAC1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL3960528 | 0.85 | MDM4 (0.50) | HDAC1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL4999756 | 0.84 | SMN1; SMN2 (0.52) | HDAC1KMT2AALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079525-A1 | CALCIUM RECEPTOR MODULATING AGENTS | Amgen Inc. (US) | 2009-07-22 | — | — | EP | disclosed |
| WO-2008057282-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2008-05-15 | — | — | WO | disclosed |