Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4990054 | 1.00 | HDAC1 (0.53) | HDAC1HDAC8HDAC6SMN1; SMN2MAPT | |
| SCHEMBL4540069 | 0.92 | HDAC1 (0.61) | HDAC1HDAC8HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL4999656 | 0.92 | HDAC1 (0.61) | HDAC1HDAC8HDAC6SMN1; SMN2MEN1 | |
| SCHEMBL4542218 | 0.90 | TSHR (0.55) | HDAC1SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL4999726 | 0.90 | TSHR (0.55) | HDAC1SMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL4999756 | 0.89 | SMN1; SMN2 (0.52) | HDAC1SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL4999705 | 0.88 | HDAC1 (0.45) | HDAC1HDAC8HDAC6SMN1; SMN2MAPT | |
| SCHEMBL4996347 | 0.88 | SMN1; SMN2 (0.48) | HDAC1SMN1; SMN2MEN1KMT2ARAB9A | |
| SCHEMBL3960528 | 0.87 | MDM4 (0.50) | HDAC1HDAC8HDAC6SMN1; SMN2MAPT | |
| SCHEMBL4999677 | 0.87 | MDM4 (0.50) | HDAC1HDAC8HDAC6SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079525-A1 | CALCIUM RECEPTOR MODULATING AGENTS | Amgen Inc. (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008057282-A1 | CALCIUM RECEPTOR MODULATING AGENTS | AMGEN INC. (US) | 2008-05-15 | — | — | WO | claimed |