Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4541432 | 0.83 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTMAPK1POLB | |
| SCHEMBL4542687 | 0.83 | MAPT (0.45) | ALDH1A1MAPTSMN1; SMN2MAPK1POLB | |
| SCHEMBL15051234 | 0.82 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL15058197 | 0.80 | MAPK1 (0.49) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL4539851 | 0.79 | MAPT (0.42) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL2464904 | 0.79 | TDP1 (0.46) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL3343914 | 0.79 | MEN1 (0.57) | ALDH1A1LMNAMAPTSMN1; SMN2HPGD | |
| SCHEMBL8072110 | 0.78 | ALDH1A1 (0.44) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 | |
| SCHEMBL28999954 | 0.78 | MAPT (0.46) | ALDH1A1LMNAMAPTSMN1; SMN2HPGD | |
| SCHEMBL29271622 | 0.78 | SMN1; SMN2 (0.46) | ALDH1A1LMNAMAPTSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009117421-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-09-24 | — | — | WO | disclosed |