SCHEMBL4540587

SCHEMBL4540587

CNS(=O)(=O)c1ccc([C@@H](Oc2ccc3c(cnn3-c3ccc(F)cc3)c2)[C@H](C)NS(=O)(=O)C2CC2)cc1

nearest known ligand 0.87

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR3C1 P04150 20/20 0.87
PGR P06401 3/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL412306 0.93 NR3C1 (1.00) NR3C1PGR
SCHEMBL441494 0.93 NR3C1 (1.00) NR3C1PGR
SCHEMBL12096210 0.93 NR3C1 (1.00) NR3C1PGR
SCHEMBL412273 0.90 NR3C1 (1.00) NR3C1PGR
SCHEMBL443728 0.90 NR3C1 (1.00) NR3C1PGR
SCHEMBL441335 0.90 NR3C1 (0.83) NR3C1PGR
SCHEMBL411298 0.90 NR3C1 (0.83) NR3C1PGR
SCHEMBL443793 0.89 NR3C1 (1.00) NR3C1PGR
SCHEMBL411893 0.89 NR3C1 (1.00) NR3C1PGR
SCHEMBL413128 0.89 NR3C1 (1.00) NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2097384-A1 INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS AstraZeneca AB (SE) 2009-09-09 EP claimed
WO-2008063116-A1 INDOZALYL SULPHONAMIDE DERIVATIVES USEFUL AS GLUCOCORTICOID MODULATORS ASTRAZENECA AB (SE) 2008-05-29 WO claimed