Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.82 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.82 |
| ▸ | STK3 | Q13188 | 6/20 | 0.82 |
| ▸ | STK4 | Q13043 | 5/20 | 0.82 |
| ▸ | SRC | P12931 | 2/20 | 0.82 |
| ▸ | KDR | P35968 | 2/20 | 0.82 |
| ▸ | BTK | Q06187 | 2/20 | 0.82 |
| ▸ | STK25 | O00506 | 1/20 | 0.82 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.82 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.82 |
| ▸ | GAK | O14976 | 1/20 | 0.82 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.82 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.82 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.82 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.82 |
| ▸ | STK17B | O94768 | 1/20 | 0.82 |
| ▸ | STK10 | O94804 | 1/20 | 0.82 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.82 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.82 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4540611 | 1.00 | EGFR (0.82) | EGFRERBB2STK3STK4SRC | |
| SCHEMBL2386955 | 0.95 | EGFR (0.83) | EGFRERBB2STK3STK4SRC | |
| SCHEMBL29801718 | 0.95 | EGFR (0.83) | EGFRERBB2STK3STK4SRC | |
| SCHEMBL2386963 | 0.95 | EGFR (0.83) | EGFRERBB2STK3STK4SRC | |
| SCHEMBL5020000 | 0.94 | EGFR (0.83) | EGFRERBB2STK3STK4SRC | |
| SCHEMBL17570820 | 0.92 | EGFR (0.88) | EGFRERBB2STK3STK4SRC | |
| SCHEMBL18780473 | 0.92 | EGFR (0.87) | EGFRERBB2STK3STK4SRC | |
| SCHEMBL31661612 | 0.92 | EGFR (0.87) | EGFRERBB2STK3STK4SRC | |
| SCHEMBL30185817 | 0.91 | EGFR (0.85) | EGFRERBB2STK3STK4SRC | |
| SCHEMBL28970453 | 0.91 | EGFR (0.85) | EGFRERBB2STK3STK4SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946224-B2 | Substituted [1,2,4]triazolo[4,3-A]pyrazines for medicaments and pharmaceutical compositions | REDX PHARMA LIMITED (GB) | 2015-02-03 | — | — | US | disclosed |
| EP-2638007-A2 | DRUG DERIVATIVES | Redx Pharma Limited (GB) | 2013-09-18 | — | — | EP | disclosed |
| US-20130225594-A1 | DRUG DERIVATIVES | REDX PHARMA PLC (GB) | 2013-08-29 | — | — | US | disclosed |
| WO-2012063085-A2 | DRUG DERIVATIVES | REDX PHARMA LIMITED (GB) | 2012-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225594-A1 | DRUG DERIVATIVES | SQOR, NQO1, CYP2D6 | EGFR 1413/4885ERBB2 655/4885STK3 2958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.