Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 10/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1818816 | 0.89 | PTGES2 (0.42) | HTR6P2RX7BRD4ALDH1A1 | |
| SCHEMBL4536214 | 0.89 | NR1I2 (0.52) | NR1I2HTR6BRD4ALDH1A1HTT | |
| SCHEMBL3903978 | 0.88 | GSPT1 (0.41) | NR1I2HTR6P2RX7BRD4PFKFB3 | |
| SCHEMBL4540174 | 0.84 | NR1I2 (0.52) | NR1I2HTR6BRD4ALDH1A1HTT | |
| SCHEMBL1831975 | 0.82 | GSPT1 (0.40) | NR1I2HTR6P2RX7BRD4ALDH1A1 | |
| SCHEMBL3906145 | 0.79 | MAP2K4 (0.39) | BRD4ALDH1A1HTTHDAC1 | |
| SCHEMBL3907047 | 0.79 | BRAF (0.44) | HDAC1 | |
| SCHEMBL3918595 | 0.78 | GSPT1 (0.42) | NR1I2BRD4ALDH1A1 | |
| SCHEMBL1810508 | 0.78 | NR1I2 (0.48) | NR1I2HTR6BRD4FABP4FABP5 | |
| SCHEMBL3907924 | 0.77 | TP53 (0.44) | PTPN2PTPN1PTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-B1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |