Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 8/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4536214 | 0.91 | NR1I2 (0.52) | NR1I2HTR6PARP1F2ALDH1A1 | |
| SCHEMBL1809645 | 0.87 | PTGES2 (0.46) | NR1I2ALDH1A1BRD4PGR | |
| SCHEMBL3904615 | 0.85 | GSPT1 (0.43) | NR1I2ALDH1A1BRD4 | |
| SCHEMBL4540841 | 0.84 | NR1I2 (0.47) | NR1I2HTR6ALDH1A1HTTPFKFB3 | |
| SCHEMBL3908715 | 0.82 | ITGA1 (0.51) | NR1I2ALDH1A1BRD4 | |
| SCHEMBL3903016 | 0.80 | NR1I2 (0.48) | NR1I2ALDH1A1BRD4 | |
| SCHEMBL3906659 | 0.80 | PTGES2 (0.47) | NR1I2ALDH1A1BRD4PGR | |
| SCHEMBL1819641 | 0.79 | PGR (0.57) | BRD4PTPN2PTPN1PGR | |
| SCHEMBL3905782 | 0.79 | GSPT1 (0.41) | NR1I2ALDH1A1BRD4 | |
| SCHEMBL3918595 | 0.78 | GSPT1 (0.42) | NR1I2ALDH1A1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-B1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |