Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.43 |
| ▸ | AKT2 | P31751 | 4/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4542245 | 0.91 | AKT1 (0.39) | AKT1HDAC8CTSVCTSLCTSB | |
| SCHEMBL4541166 | 0.85 | AKT1 (0.45) | AKT1AKT2AKT3HDAC8CTSV | |
| SCHEMBL4378512 | 0.83 | AKT1 (0.40) | AKT1AKT2AKT3 | |
| SCHEMBL4539905 | 0.82 | AKT1 (0.41) | AKT1HDAC8CTSVCTSLCTSB | |
| SCHEMBL4543920 | 0.82 | HDAC8 (0.36) | HDAC8CTSVCTSLCTSBCTSS | |
| SCHEMBL4543909 | 0.82 | HDAC8 (0.39) | AKT1HDAC8CTSVCTSLCTSB | |
| SCHEMBL1529471 | 0.82 | AKT1 (0.59) | AKT1AKT2AKT3HDAC8CTSV | |
| SCHEMBL4554202 | 0.82 | CTSV (0.42) | HDAC8CTSVCTSLCTSBCTSS | |
| SCHEMBL4540224 | 0.82 | HDAC8 (0.38) | HDAC8CTSVCTSLCTSBCTSS | |
| SCHEMBL1529378 | 0.80 | AKT1 (0.61) | AKT1AKT2AKT3HDAC8CTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117523-A1 | INHIBITORS OF AKT ACTIVITY | SmithKline Beecham Corporation (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008098104-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |