Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.81 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL443904 | 0.90 | HDAC8 (1.00) | HDAC8HDAC6 | |
| SCHEMBL443905 | 0.78 | HDAC8 (0.56) | HDAC8HCAR3SMN1; SMN2GAANPC1 | |
| SCHEMBL456939 | 0.78 | HDAC8 (0.79) | HDAC8HDAC6 | |
| SCHEMBL2793284 | 0.75 | GAA (0.58) | HDAC8HCAR3SMN1; SMN2GAANPC1 | |
| SCHEMBL3318993 | 0.74 | HDAC8 (0.56) | HDAC8SMN1; SMN2GAANPC1MAPT | |
| SCHEMBL444505 | 0.74 | HDAC8 (1.00) | HDAC8HDAC6 | |
| SCHEMBL2789965 | 0.72 | MAPT (0.55) | HDAC8HCAR3SMN1; SMN2GAAMAPT | |
| SCHEMBL2789608 | 0.72 | LMNA (0.59) | HDAC8HCAR3SMN1; SMN2GAAMAPT | |
| SCHEMBL8177053 | 0.72 | GRIN2B (0.57) | HDAC8GAANPC1MAPTRAB9A | |
| SCHEMBL15680661 | 0.72 | HDAC8 (0.71) | HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613775-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F.HOFFMANN-LA ROCHE AG (CH) | 2013-07-17 | — | — | EP | claimed |
| WO-2012031993-A1 | NOVEL N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2012-03-15 | — | — | WO | claimed |