Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.48 |
| ▸ | MET | P08581 | 5/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.48 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | ABL2 | P42684 | 1/20 | 0.48 |
| ▸ | FRK | P42685 | 1/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2252983 | 1.00 | KDR (0.48) | KDRMETMAPK14NTRK1ABL1 | |
| SCHEMBL2249560 | 1.00 | KDR (0.48) | KDRMETMAPK14NTRK1ABL1 | |
| SCHEMBL2255067 | 0.96 | KDR (0.46) | KDRMETMAPK14NTRK1ABL1 | |
| SCHEMBL2254742 | 0.96 | KDR (0.51) | KDRMETMAPK14NTRK1ABL1 | |
| SCHEMBL2250948 | 0.95 | KDR (0.46) | KDRMETMAPK14NTRK1ABL1 | |
| SCHEMBL3551082 | 0.94 | KDR (0.44) | KDRMETMAPK14NTRK1ABL1 | |
| SCHEMBL3552505 | 0.94 | KDR (0.44) | KDRMETMAPK14NTRK1ABL1 | |
| SCHEMBL3558389 | 0.94 | KDR (0.48) | KDRMETMAPK14NTRK1ABL1 | |
| SCHEMBL3553004 | 0.94 | KDR (0.48) | KDRMETMAPK14NTRK1ABL1 | |
| SCHEMBL2250429 | 0.93 | MET (0.55) | KDRMETMAPK14NTRK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119706-A1 | PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE | Eisai R&D Management Co., Ltd. (JP) | 2009-11-18 | — | — | EP | disclosed |