⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28350486 | 0.77 | — | — | |
| SCHEMBL4033993 | 0.68 | — | — | |
| Iodide SCHEMBL7534252 | 0.67 | — | — | |
| SCHEMBL2641486 | 0.65 | — | — | |
| SCHEMBL2783514 | 0.63 | — | — | |
| Iodide SCHEMBL7532133 | 0.63 | — | — | |
| SCHEMBL21181266 | 0.62 | — | — | |
| SCHEMBL17847691 | 0.60 | — | — | |
| SCHEMBL18569941 | 0.60 | — | — | |
| SCHEMBL29017589 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005066129-A2 | BIS-PYRIDINO CONTAINING COMPOUNDS FOR USE IN THE TREATMENT OF CNS PATHOLOGIES | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2005-07-21 | — | — | WO | claimed |
| CN-122010981-A | GLP-1 receptor agonism/GLP-1 secretagogue double-target compound | 仁奎医药科技(北京)有限公司 | 2026-05-12 | — | — | CN | disclosed |
| US-12617805-B2 | Codrug that disintegrates in intestine, preparation therefor, and use thereof | ENNOVABIO (ZHEJIANG) PHARMACEUTICALS CO., LTD. (CN) | 2026-05-05 | — | — | US | disclosed |
| CN-120118079-A | Isoquinoline medicine and application thereof in improving or treating digestive tract tumor | 合肥综合性国家科学中心大健康研究院 | 2025-06-10 | — | — | CN | disclosed |
| CN-120118080-A | Medicine for improving chronic atrophic gastritis and application thereof | 合肥综合性国家科学中心大健康研究院 | 2025-06-10 | — | — | CN | disclosed |
| CN-120081839-A | Berberine isoquinoline derivative, preparation method thereof and application thereof in resisting multiple myeloma | 南京中医药大学 | 2025-06-03 | — | — | CN | disclosed |
| CN-118845772-A | Berberine vitamin C salt composition, preparation method and application thereof | 杭州居维叶生物医药有限公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-117137916-A | Application of hydrochloric acid demethyleneberberine in preparing medicament for preventing or treating psoriasis | 中国药科大学 | 2023-12-01 | — | — | CN | disclosed |
| US-20230271982-A1 | CODRUG THAT DISINTEGRATES IN INTESTINE, PREPARATION THEREFOR, AND USE THEREOF | SHANGHAI ENNOVABIO PHARMACEUTICALS CO., LTD. (CN) | 2023-08-31 | — | — | US | disclosed |
| EP-4186900-A1 | CODRUG THAT DISINTEGRATES IN INTESTINE, PREPARATION THEREFOR, AND USE THEREOF | Ennovabio (Zhejiang) Pharmaceuticals Co., Ltd. (CN) | 2023-05-31 | — | — | EP | disclosed |
| CN-115990160-A | Application of demethyleneberberine hydrochloride in preparation of medicines for preventive treatment of pseudomonas aeruginosa pneumonia | 中国药科大学 | 2023-04-21 | — | — | CN | disclosed |
| CN-115715292-A | 1H-pyrazolo [4,3-g ] isoquinoline and 1H-pyrazolo [4,3-g ] quinoline derivatives as alpha-1-antitrypsin modulators for the treatment of alpha-1-antitrypsin deficiency (AATD) | 弗特克斯药品有限公司 | 2023-02-24 | — | — | CN | disclosed |
| WO-2022055218-A1 | COMPOSITION FOR PREVENTING OR TREATING HAIR LOSS, COMPRISING EXTRACT OF CORYDALIS YANHUSUO | 주식회사 종근당 | 2022-03-17 | — | — | WO | disclosed |
| CN-110372689-A | R9With R10The hydrophily berberine type derivative of connection and its application for preparing drug | 中国医学科学院药物研究所 | 2019-10-25 | — | — | CN | disclosed |
| CN-110179792-A | Berberine salt, ursodeoxycholic hydrochlorate, related compound and its preparation method and application | 深圳君圣泰生物技术有限公司 | 2019-08-30 | — | — | CN | disclosed |
| CN-106687460-B | Berberine salt, ursodeoxycholate, related compound and preparation method and application thereof | 深圳君圣泰生物技术有限公司 | 2019-05-17 | — | — | CN | disclosed |
| CN-106687460-A | Berberine salt, ursodeoxycholate, related compound and preparation method and application thereof | 深圳君圣泰生物技术有限公司 | 2017-05-17 | — | — | CN | disclosed |
| EP-2637649-A2 | COMPOUNDS AND METHODS FOR TREATING PAIN | Akron Molecules GmbH (AT) | 2013-09-18 | — | — | EP | disclosed |
| WO-2012062925-A2 | COMPOUNDS AND METHODS FOR TREATING PAIN | AKRON MOLECULES GMBH (AT) | 2012-05-18 | — | — | WO | disclosed |
| US-5738788-A | POROUS MATERIAL COVERED WITH A CATIONIC POLYVINYL ACETAL/ALCOHOL CROSSLINKED THROUGH PHOTOSENSITIVE GROUPS; EFFICIENCY, DURABILITY, CLOGGING RESISTANCE; ELECTROSTATIC WATER FILTRATION | JAPAN VILENE COMPANY LTD. (JP) | 1998-04-14 | — | — | US | disclosed |