Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TEAD3 | Q99594 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL345616 | 0.83 | TSHR (0.58) | TSHRKDM4EPOLBL3MBTL1LTA4H | |
| SCHEMBL10821588 | 0.80 | TSHR (0.54) | TSHRKDM4EPOLBL3MBTL1LTA4H | |
| SCHEMBL21068659 | 0.80 | TSHR (0.54) | TSHRKDM4EPOLBL3MBTL1LTA4H | |
| SCHEMBL25312129 | 0.80 | TSHR (0.54) | TSHRKDM4EPOLBL3MBTL1LTA4H | |
| SCHEMBL9329658 | 0.80 | TSHR (0.54) | TSHRKDM4EPOLBL3MBTL1LTA4H | |
| SCHEMBL23249922 | 0.80 | TSHR (0.54) | TSHRKDM4EPOLBL3MBTL1LTA4H | |
| SCHEMBL18282346 | 0.79 | TSHR (0.52) | TSHRKDM4EPOLBL3MBTL1LTA4H | |
| SCHEMBL17941033 | 0.79 | L3MBTL1 (0.53) | TSHRKDM4EPOLBL3MBTL1LTA4H | |
| SCHEMBL30736988 | 0.79 | TSHR (0.52) | TSHRKDM4EPOLBL3MBTL1LTA4H | |
| SCHEMBL96049 | 0.78 | TSHR (0.56) | TSHRKDM4EPOLBL3MBTL1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012062229-A1 | A METHOD OF MANUFACTURING (-)-L-(3-HYDROXYPROPYL)-5-[(2R)-2-({2,2,2-TRIFLUOROETHOXY)- PHENOXYETHYL}AMINO)PROPYL]-2,3-DIHYDRO-LH-INDOLE-7-CARBOXAMIDE | ZENTIVA, K.S. (CZ) | 2012-05-18 | — | — | WO | disclosed |