Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | GRB2 | P62993 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 5/20 | 0.46 |
| ▸ | PPARA | Q07869 | 5/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 2/20 | 0.42 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.42 |
| ▸ | NMT1 | P30419 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957756 | 0.86 | SLC6A4 (0.78) | SLC6A4PPARGPPARASLC6A2SLC6A3 | |
| SCHEMBL1779366 | 0.86 | SLC6A4 (0.78) | SLC6A4PPARGPPARASLC6A2SLC6A3 | |
| SCHEMBL652674 | 0.86 | SLC6A4 (0.78) | SLC6A4PPARGPPARASLC6A2SLC6A3 | |
| SCHEMBL2033002 | 0.77 | SLC6A4 (0.64) | SLC6A4PPARGPPARASLC6A2SLC6A3 | |
| SCHEMBL288206 | 0.77 | SLC6A4 (0.64) | SLC6A4PPARGPPARASLC6A2SLC6A3 | |
| SCHEMBL2031957 | 0.77 | SLC6A4 (0.64) | SLC6A4PPARGPPARASLC6A2SLC6A3 | |
| Trifluoroacetic Acid SCHEMBL1764774 | 0.77 | GRB2 (0.48) | SLC6A4GRB2PPARGPPARASLC6A2 | |
| Trifluoroacetic Acid SCHEMBL4358439 | 0.77 | GRB2 (0.40) | GRB2DPP4DPP8DPP7PTPN1 | |
| Trifluoroacetic Acid SCHEMBL4358433 | 0.77 | GRB2 (0.40) | GRB2DPP4DPP8DPP7PTPN1 | |
| Trifluoroacetic Acid SCHEMBL588954 | 0.76 | DPP4 (0.45) | GRB2DPP4PTPN1ANPEPENPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1653961-A4 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORP (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20080255143-A1 | Inhibitors of Akt Activity | SMITHKLINE BEECHAM CORPORATION (PA) | 2008-10-16 | — | — | US | disclosed |
| CN-1859912-A | Inhibitors of Akt activity | SMITHKLINE BEECHAM CORP (US) | 2006-11-08 | — | — | CN | disclosed |
| EP-1653961-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005011700-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255143-A1 | Inhibitors of Akt Activity | PI4KB, PIK3CA, AKT2 | SLC6A4 4637/4885GRB2 210/4885PPARG 2525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.