Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969037 | 0.91 | MAP2K1 (0.43) | MAP2K1MAP2K2HDAC1HDAC6SYK | |
| SCHEMBL3971570 | 0.87 | MAP2K1 (0.52) | MAP2K1MAP2K2 | |
| SCHEMBL3975542 | 0.86 | MAP2K1 (0.49) | MAP2K1MAP2K2KDM4EDHODH | |
| SCHEMBL3969033 | 0.84 | MAP2K1 (0.45) | MAP2K1MAP2K2KDM4EDHODHIDO1 | |
| SCHEMBL1488520 | 0.84 | MAP2K1 (0.59) | MAP2K1MAP2K2AURKATNFRSF1AKDR | |
| SCHEMBL1488560 | 0.84 | MAP2K1 (0.60) | MAP2K1MAP2K2KDM4E | |
| SCHEMBL29413590 | 0.84 | MAP2K1 (0.60) | MAP2K1MAP2K2KDM4E | |
| SCHEMBL3971457 | 0.78 | CSF1R (0.43) | MAP2K1MAP2K2KDM4EHDAC6SYK | |
| SCHEMBL3979835 | 0.78 | MAP2K1 (0.50) | MAP2K1KDM4E | |
| SCHEMBL3974178 | 0.78 | MAP2K1 (0.47) | MAP2K1MAP2K2DHODHSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673339-A4 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC (US) | 2009-04-29 | — | — | EP | disclosed |
| EP-1673339-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | Array Biopharma, Inc. (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005023759-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-03-17 | — | — | WO | disclosed |