SCHEMBL4546334

SCHEMBL4546334

O=C(Nc1ccccc1)C1CCN(c2ncccc2C(F)(F)F)CC1

nearest known ligand 0.84

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 4/20 0.84
MALT1 Q9UDY8 5/20 0.71
RBP4 P02753 1/20 0.61
HSD17B10 Q99714 1/20 0.57
HSD11B1 P28845 1/20 0.57
RXFP1 Q9HBX9 2/20 0.54
NOTUM Q6P988 1/20 0.54
KMT2A Q03164 1/20 0.54
HTT P42858 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1250860 0.87 TRPV1 (0.78) TRPV1MALT1RBP4HSD11B1
SCHEMBL9942050 0.87 TRPV1 (0.76) TRPV1MALT1RBP4
SCHEMBL12910238 0.87 TRPV1 (0.76) TRPV1MALT1RBP4
SCHEMBL1252470 0.84 TRPV1 (0.66) TRPV1MALT1RBP4HSD11B1NOTUM
SCHEMBL12909389 0.84 MALT1 (0.69) TRPV1MALT1RBP4HSD17B10KMT2A
SCHEMBL4546335 0.84 TRPV1 (0.63) TRPV1MALT1RBP4HSD11B1RXFP1
SCHEMBL13714900 0.83 MALT1 (1.00) TRPV1MALT1HSD17B10
SCHEMBL3216080 0.79 TRPV1 (0.69) TRPV1RBP4HSD11B1
SCHEMBL12779444 0.78 TRPV1 (0.61) TRPV1MALT1RBP4RXFP1
SCHEMBL3932323 0.78 TRPV1 (0.62) TRPV1MALT1RBP4HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8168827-B2 Amide derivative AJINOMOTO CO., INC. (JP) 2012-05-01 US disclosed
US-20090258900-A1 AMIDE DERIVATIVE AJINOMOTO CO. INC (JP) 2009-10-15 US disclosed
US-7572815-B2 Amide derivative AJINOMOTO CO., INC. (JP) 2009-08-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090258900-A1 AMIDE DERIVATIVE NR0B1, NR0B2, NR1I3 TRPV1 804/4885MALT1 2829/4885RBP4 1756/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.