Pabetan

Pabetan

SCHEMBL4546522

N=C(N)NCCC[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)Nc1ccc2ccccc2c1

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
NPY4R P50391 12/20 0.46
NPY1R P25929 7/20 0.46
NPY2R P49146 5/20 0.46
NPY5R Q15761 5/20 0.46
KISS1R Q969F8 3/20 0.43
FCER2 P06734 1/20 0.41
TRHDE Q9UKU6 1/20 0.41
EPHX1 P07099 1/20 0.41
CTSD P07339 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pabetan SCHEMBL14928984 1.00 NPY4R (0.46) NPY4RNPY1RNPY2RNPY5RKISS1R
Pabetan SCHEMBL21571465 1.00 NPY4R (0.46) NPY4RNPY1RNPY2RNPY5RKISS1R
Pabetan SCHEMBL29894618 1.00 NPY4R (0.46) NPY4RNPY1RNPY2RNPY5RKISS1R
SCHEMBL8341764 0.91 NPY4R (0.47) NPY4RNPY1RNPY2RNPY5REPHX1
SCHEMBL27352129 0.91 NPY4R (0.47) NPY4RNPY1RNPY2RNPY5REPHX1
SCHEMBL7850376 0.89 NPY4R (0.49) NPY4RNPY1RNPY2RNPY5RKISS1R
SCHEMBL7859111 0.89 NPY4R (0.49) NPY4RNPY1RNPY2RNPY5RKISS1R
SCHEMBL7850373 0.89 NPY4R (0.49) NPY4RNPY1RNPY2RNPY5RKISS1R
SCHEMBL7859109 0.89 NPY4R (0.49) NPY4RNPY1RNPY2RNPY5RKISS1R
SCHEMBL7857092 0.88 NPY4R (0.48) NPY4RNPY1RNPY2RNPY5RKISS1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023028364-A1 TARGETED COMPOSITIONS AND USES THEROF SEPELO THERAPEUTICS, LLC (US) 2023-03-02 WO claimed
US-6251869-B1 SUCH AS L-PHENYLALANYL-L-ARGINYL-BETA-NAPHTHYLAMIDE; FOR TREATING GRAM-NEGATIVE ORGANISMS INFECTIONS IN MAMMALS PHARMACIA & UPJOHN COMPANY 2001-06-26 US claimed
EP-1077718-A1 ENHANCEMENT OF OXAZOLIDINONE ANTIBACTERIAL AGENTS ACTIVITY BY ARGININE DERIVATIVES PHARMACIA & UPJOHN COMPANY (US) 2001-02-28 EP claimed
WO-1999059616-A1 ENHANCEMENT OF OXAZOLIDINONE ANTIBACTERIAL AGENTS ACTIVITY BY USING ARGININE DERIVATIVES PHARMACIA & UPJOHN COMPANY (US) 1999-11-25 WO claimed
EP-0554314-B1 A METHOD OF DETERMINING PORPHYROMONAS GINGIVALIS WIKSTROEM MAUDE BIRGITTA (SE) 1996-08-14 EP claimed
WO-2023028364-A1 TARGETED COMPOSITIONS AND USES THEROF SEPELO THERAPEUTICS, LLC (US) 2023-03-02 WO disclosed
WO-2022046997-A1 BAMA-BINDING AGENTS AND METHODS OF USE THEREOF NGM BIOPHARMACEUTICALS, INC. (US) 2022-03-03 WO disclosed
US-20190352339-A1 PEPTIDE INHIBITOR OF TRANSMEMBRANE PORE FORMATION AND EFFLUXPUMP FUNCTION IN A SMALL MULTIDRUG RESISTANCE PROTEIN FROM PSEUDOMONAS AERUGINOSA HOSPITAL FOR SICK CHILDREN (CA) 2019-11-21 US disclosed
EP-2987787-A1 NOVEL COMPOUND WITH ANTIBACTERIAL ACTIVITY Juntendo Educational Foundation (JP) 2016-02-24 EP disclosed
US-9115169-B2 Method of treating tumors LYTIX BIOPHARMA AS (NO) 2015-08-25 US disclosed
US-20120108520-A1 Antimicrobial Compounds and Formulations LYTIX BIOPHARMA AS (NO) 2012-05-03 US disclosed
US-8048852-B2 Antimicrobial compounds and formulations LYTIX BIOPHARMA AS (NO) 2011-11-01 US disclosed
WO-1999059616-A1 ENHANCEMENT OF OXAZOLIDINONE ANTIBACTERIAL AGENTS ACTIVITY BY USING ARGININE DERIVATIVES PHARMACIA & UPJOHN COMPANY (US) 1999-11-25 WO disclosed
US-5981164-A RAPID AND SIMPLE DIAGNOSIS OF PERIODONTITIS BY REACTING SAMPLE WITH SUBSTRATE FOR TRYPSIN-LIKE AMIDASE, A MARKER SYSTEM, AND A MONO- OR DIPEPTIDE ENHANCER CONTAINING GLYCINE DERIVATIVE; ANALYZING MIXTURE FOR SIGNAL GENERATED BY MARKER WIKSTROEM MAUDE BIRGITTA (SE) 1999-11-09 US disclosed
EP-0554314-B1 A METHOD OF DETERMINING PORPHYROMONAS GINGIVALIS WIKSTROEM MAUDE BIRGITTA (SE) 1996-08-14 EP disclosed
EP-0554314-A1 A METHOD OF DETERMINING PORPHYROMONAS GINGIVALIS. WIKSTROEM MAUDE BIRGITTA (SE) 1993-08-11 EP disclosed
EP-0255341-B1 REAGENT FOR TESTING PERIODONTAL DISEASES SUNSTAR KABUSHIKI KAISHA (JP) 1993-02-03 EP disclosed
US-5137811-A Method for diagnosing periodontal diseases with a substrate specific for aminopeptidase activity of periodontopathic bacteria SUNSTAR KABUSHIKI KAISHA (JP) 1992-08-11 US disclosed
WO-1992007086-A1 A METHOD OF DETERMINING PORPHYROMONAS GINGIVALIS WIKSTROEM MAUDE BIRGITTA (SE) 1992-04-30 WO disclosed
EP-0255341-A2 Reagent for testing periodontal diseases SUNSTAR KABUSHIKI KAISHA (JP) 1988-02-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120108520-A1 Antimicrobial Compounds and Formulations VIP, NONO, CLPTM1 NPY4R 2699/4885NPY1R 2746/4885NPY2R 2193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.