SCHEMBL454692

SCHEMBL454692

N#Cc1cc(F)cc(C2CCCN2)c1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.38
CHRNA7 P36544 2/20 0.38
CHRNA4 P43681 2/20 0.38
DRD2 P14416 1/20 0.38
DRD3 P35462 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
TRPM5 Q9NZQ8 1/20 0.38
KCNH2 Q12809 1/20 0.37
PARP1 P09874 1/20 0.36
PGR P06401 4/20 0.35
MEN1 O00255 2/20 0.34
CYP2D6 P10635 2/20 0.34
CYP2C19 P33261 2/20 0.34
KMT2A Q03164 2/20 0.34
POLB P06746 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP2A6 P11509 1/20 0.34
CYP2C9 P11712 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17067858 1.00 CHRNB2 (0.38) CHRNB2CHRNA7CHRNA4DRD2DRD3
SCHEMBL15039527 0.84 CHRNB2 (0.46) CHRNB2CHRNA7CHRNA4L3MBTL1KCNH2
SCHEMBL18704814 0.84 CHRNB2 (0.46) CHRNB2CHRNA7CHRNA4L3MBTL1KCNH2
SCHEMBL21723224 0.84 CHRNB2 (0.46) CHRNB2CHRNA7CHRNA4L3MBTL1KCNH2
Hydrochloric Acid SCHEMBL15017116 0.83 CHRNB2 (0.44) CHRNB2CHRNA7CHRNA4L3MBTL1KCNH2
Hydrochloric Acid SCHEMBL15017117 0.83 CHRNB2 (0.44) CHRNB2CHRNA7CHRNA4L3MBTL1KCNH2
SCHEMBL2708320 0.79 MEN1 (0.47) CHRNB2CHRNA7CHRNA4L3MBTL1KCNH2
SCHEMBL22097409 0.77 KCNH2 (0.41) CHRNB2CHRNA7CHRNA4L3MBTL1KCNH2
SCHEMBL22089706 0.77 CHRNB2 (0.40) CHRNB2CHRNA7CHRNA4L3MBTL1KCNH2
SCHEMBL2240758 0.77 CHRNB2 (0.40) CHRNB2CHRNA7CHRNA4L3MBTL1TRPM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012116217-A1 COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS IRM LLC (BM) 2012-08-30 WO disclosed
WO-2012034095-A1 COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS IRM LLC (BM) 2012-03-15 WO disclosed
WO-2012034095-A1 COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS IRM LLC (BM) 2012-03-15 WO disclosed