Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.31 |
| ▸ | GCGR | P47871 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1848750 | 0.90 | BRAF (0.42) | BRAFCKS1BSKP2MAP2K4 | |
| SCHEMBL1846650 | 0.85 | CKS1B (0.46) | BRAFCKS1BSKP2MAP2K4 | |
| SCHEMBL1852972 | 0.79 | SLC22A12 (0.42) | BRAF | |
| SCHEMBL1848477 | 0.78 | BRAF (0.40) | BRAF | |
| SCHEMBL1846750 | 0.77 | BRAF (0.40) | BRAF | |
| SCHEMBL1847876 | 0.77 | BRAF (0.55) | BRAF | |
| SCHEMBL1847624 | 0.76 | CYP2C9 (0.42) | BRAF | |
| SCHEMBL1849216 | 0.75 | BRAF (0.42) | BRAFCKS1BSKP2 | |
| SCHEMBL1848024 | 0.74 | BRAF (0.42) | BRAF | |
| SCHEMBL1848453 | 0.69 | IMPDH2 (0.35) | GCGRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324008-B1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2012-05-09 | — | — | EP | disclosed |