Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | CARM1 | Q86X55 | 5/20 | 0.37 |
| ▸ | PRMT6 | Q96LA8 | 5/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963156 | 0.85 | KDM1A (0.49) | KDM1ABRD4ATAD2CARM1PRMT6 | |
| SCHEMBL4547142 | 0.79 | KDM1A (0.48) | KDM1ABRD4ATAD2EHMT2HTR4 | |
| SCHEMBL18551063 | 0.79 | KDM1A (0.48) | KDM1ABRD4ATAD2CARM1PRMT6 | |
| SCHEMBL18551217 | 0.78 | HRH2 (0.46) | KDM1ABRD4ATAD2EHMT2LTA4H | |
| SCHEMBL18873644 | 0.78 | KDM1A (0.47) | KDM1ABRD4ATAD2CARM1PRMT6 | |
| SCHEMBL5949639 | 0.78 | HRH2 (0.46) | KDM1ABRD4ATAD2EHMT2LTA4H | |
| SCHEMBL25389091 | 0.77 | KDM1A (0.47) | KDM1ACARM1PRMT6LTA4HHTR4 | |
| Hydrochloric Acid SCHEMBL6496133 | 0.76 | HRH2 (0.45) | KDM1ABRD4ATAD2EHMT2LTA4H | |
| SCHEMBL2621574 | 0.76 | KDM1A (0.46) | KDM1ABRD4ATAD2EHMT2HTR4 | |
| SCHEMBL12395763 | 0.76 | KDM1A (0.46) | KDM1ABRD4ATAD2EHMT2HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304556-B2 | Thiazolyl-dihydro-indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-06 | — | — | US | disclosed |
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | KDM1A 1757/4885BRD4 645/4885ATAD2 4054/4885 |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | KDM1A 1757/4885BRD4 645/4885ATAD2 4054/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.