Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.43 |
| ▸ | KDM1A | O60341 | 3/20 | 0.40 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL454721 | 1.00 | NTRK1 (0.43) | NTRK1JAK2RIPK1KDM1ARCOR1 | |
| SCHEMBL4289056 | 0.81 | MAOB (0.45) | NTRK1JAK2RIPK1KDM1ARCOR1 | |
| SCHEMBL4096537 | 0.78 | KDM1A (0.40) | NTRK1JAK2RIPK1KDM1ARCOR1 | |
| SCHEMBL16474359 | 0.77 | KDM1A (0.46) | NTRK1JAK2RIPK1KDM1ARCOR1 | |
| SCHEMBL451781 | 0.75 | RIPK1 (0.50) | NTRK1JAK2RIPK1MAOBMAOA | |
| SCHEMBL29744544 | 0.75 | RIPK1 (0.50) | NTRK1JAK2RIPK1MAOBMAOA | |
| SCHEMBL430829 | 0.75 | RIPK1 (0.50) | NTRK1JAK2RIPK1MAOBMAOA | |
| SCHEMBL21723215 | 0.75 | RIPK1 (0.50) | NTRK1JAK2RIPK1MAOBMAOA | |
| SCHEMBL17358800 | 0.74 | RIPK1 (0.61) | NTRK1JAK2RIPK1MAOBMAOA | |
| SCHEMBL17358798 | 0.74 | RIPK1 (0.61) | NTRK1JAK2RIPK1MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614062-A1 | IMIDAZO [1, 2]PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012034091-A1 | IMIDAZO [1, 2] PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | disclosed |