SCHEMBL4549384

SCHEMBL4549384

Cc1cc(-c2cccc3c2oc2ccccc23)c(C)cc1-c1cc2ccccc2c2ccccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 2/20 0.51
PRKDC P78527 4/20 0.41
PIK3CD O00329 1/20 0.41
PIK3CB P42338 1/20 0.41
ALDH1A1 P00352 4/20 0.40
HPGD P15428 3/20 0.40
HSD17B10 Q99714 3/20 0.40
TSHR P16473 1/20 0.40
MAPK1 P28482 1/20 0.40
CASP1 P29466 1/20 0.40
HIF1A Q16665 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
HDAC8 Q9BY41 1/20 0.38
CYP1A2 P05177 1/20 0.38
MAOA P21397 2/20 0.38
MAOB P27338 1/20 0.38
GGPS1 O95749 1/20 0.38
ATM Q13315 1/20 0.38
AHR P35869 1/20 0.36
MEN1 O00255 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16302981 0.92 ALOX5 (0.58) ALOX5PRKDCPIK3CDPIK3CBALDH1A1
SCHEMBL4549368 0.91 ALOX5 (0.56) ALOX5PRKDCPIK3CDPIK3CBALDH1A1
SCHEMBL4549370 0.91 ALOX5 (0.56) ALOX5PRKDCPIK3CDPIK3CBALDH1A1
SCHEMBL4549396 0.91 ALOX5 (0.56) ALOX5PRKDCPIK3CDPIK3CBALDH1A1
SCHEMBL4549369 0.89 ALOX5 (0.59) ALOX5PRKDCPIK3CDPIK3CBALDH1A1
SCHEMBL15195398 0.85 ALOX5 (0.51) ALOX5PRKDCPIK3CDPIK3CBALDH1A1
SCHEMBL23989115 0.84 ALOX5 (0.52) ALOX5PRKDCPIK3CDPIK3CBALDH1A1
SCHEMBL12203189 0.84 ALOX5 (0.55) ALOX5PRKDCPIK3CDPIK3CBHDAC8
SCHEMBL1635355 0.83 ALOX5 (0.46) ALOX5PRKDCPIK3CDPIK3CBALDH1A1
SCHEMBL4549380 0.82 ALOX5 (0.54) ALOX5PRKDCPIK3CDPIK3CBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9406889-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-08-02 US disclosed
US-9406889-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-08-02 US disclosed
US-20150171333-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-06-18 US disclosed
US-20150171333-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-06-18 US disclosed
US-8968888-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-03-03 US disclosed
US-8968888-B2 Phenanthrene compound, light-emitting element, light-emitting device, electronic device, and lighting device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2015-03-03 US disclosed
US-20120104369-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-05-03 US disclosed
US-20120104369-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-05-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120104369-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device MC1R, NR2E3, RPS19 ALOX5 3393/4885PRKDC 4132/4885PIK3CD 4546/4885
US-20150171333-A1 Phenanthrene Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device MC1R, NR2E3, RPS19 ALOX5 3393/4885PRKDC 4132/4885PIK3CD 4546/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.